Results 41 to 50 of about 2,037,165 (292)

Compact 9dBEs Enable Efficient and Precise Genome Editing in Mammalian Cells and In Vivo

Advanced Science, EarlyView.
As a compact type II‐D system, the Cas9d‐based platform holds great potential for in vivo applications. Through rational engineering, its derived base editors (9dBEs) enable efficient disease modeling while facilitating single‐vector AAV delivery for in vivo genome editing. These miniature tools offer a robust strategy for basic research and biomedical
Qingquan Xiao, Zhijin Tian, Luqi Weng, Kun Xu, Dingyi Han, Zhaowei Wu, Junnan Li, Shangpu Li, Qijing Zhang, Xiaohui Zhao, Guoling Li, Yinghui Wei, Zhen Gu   +12 more
wiley   +1 more source

Book Review: E.D. Zilivinskaya. Architecture of the Golden Horde. Part 1. Cult Monuments. Moscow; Kazan: “Otechestvo” Publ., 2014. 228 p.,+ 220 p., ill.

Поволжская археология, 2016
The reviewed monograph by E.D. Zilivinskaya is the fi rst fundamental research in the national historiography to address cult architecture of the Golden Horde.
Khuzin Fayaz Sh.
doaj  

Corynoxine Inhibits Tumor Growth via Targeting NQO1 and Modulating the PTPA–NQO1/PP2A Switch to Activate PP2A

Advanced Science, EarlyView.
Corynoxine exerts potent broad‐spectrum anticancer activity by directly targeting NQO1. This interaction dissociates the oncogenic NQO1‐PTPA complex, releasing PTPA to robustly activate the tumor suppressor PP2A. Consequently, downstream Raf/MEK/ERK and PI3K/AKT signaling pathways are suppressed, downregulating c‐Myc and driving tumor regression ...
Guoqing Hou, Li Lin, Mengjie Xia, Ruohan Liang, Yueyue Zhang, Linna Du, Xuan Cao   +6 more
wiley   +1 more source

Increased Disarray of Extracellular Matrix Collagen‐I Fiber Network and Compromised Biomechanics in Aortae From Marfan‐Syndrome Mice Assessed Through Combined Opto‐Biomechatronics

Advanced Science, EarlyView.
Combined structure‐function assessment in aortic rings from Marfan mice using MechaMorph Opto‐Biomechatronics technology relates increased elasticity (stiffness) and dynamic viscosity and less ordered extracellular matrix 3D‐structure (collagen) as potential causes for impaired Windkessel function and compromised haemodynamics in Marfan's syndrome ...
Dominik Schneidereit, Anika Nagel, Vanessa I. T. Zwaans, Laureen Schurr, Jonas Ahr, Michael Haug, Anna Piluso, Alexandra Sporkova, Matthias Karck, Andreas H. Wagner, Oliver Friedrich   +10 more
wiley   +1 more source

The role of saintly personalities in popular discourses from around 1970 on Baroque artistic cultures [PDF]

Journal of Art Historiography, 2016
This article identifies a number of concepts that have been used in popular discourse on Baroque art, architecture and visual culture on both sides of the Iron Curtain.
Ivan Gerát
doaj  

Nature of Enthusiasm

Проект Байкал, 2015
Art and architecture of the avant-guard in the beginning of 20 century supposed to be connected with the general upheaval in cultural and spiritual life.
Alexander Rappaport
doaj   +1 more source

Intrinsic Mechanical Parameters and their Characterization in Solid‐State Lithium Batteries

Advanced Energy Materials, Volume 15, Issue 11, March 18, 2025.
This review focuses on the intrinsic mechanical parameters and their associated characterization in solid‐state batteries. The physical significance of mechanics parameters is introduced with exhaustive classifications by elastic, plastic deformations and fracture in bulk, adhesion, friction at interfaces, and mechanical fatigue in cells ...
Shuai Hao, Qianyi Zhang, Xiangkang Kong, Zhaoxiang Wang, Xue‐Ping Gao, Paul R. Shearing   +5 more
wiley   +1 more source

Palace and temple complexes of the Qizhou and Feng Hao metropolitan areas of the Western Zhou Period (1027–771 BC) according to archaeological data

Шаги, 2022
The article analyzes the archaeological material of monuments in the capital centers of Qizhou and Feng-Hao of the state of Western Zhou (1027–771 BC) and of the era before the foundation of this state (ca. 1095–1027 BC).
M. V. Efimenko
doaj   +1 more source

The International Consortium for Arthrogryposis: A Collaborative Framework for Early Detection, Care, Research, and Education

American Journal of Medical Genetics Part C: Seminars in Medical Genetics, EarlyView.
ABSTRACT Arthrogryposis multiplex congenita (AMC) is a group of rare congenital conditions, characterized by multiple joint contractures but may involve any body system including central nervous system. AMC is etiologically heterogeneous, with over 400 genetic and many non‐genetic causes implicated in its prenatal development.
Shahrzad Nematollahi, Noa Bouzaglo, Victoria Castillo Sanchez, Johanna I. P. de‐Vries, Klaus Dieterich, Alicja Fafara, Isabel Filges, Philip Giampietro, Göknur Haliloğlu, Judith Hall, Coleman Hilton, Remco Jansen, Valentina Maestri, Carolina Navalon, Daniel Natera de Benito, Tony Pan, Ani Samargian, Bonita Sawatzky, Harold van Bosse, Paul A. Trainor, Noémi Dahan‐Oliel   +20 more
wiley   +1 more source

Scientific Baroque – for everyone. Constructing and conveying an art epoch during the Stalinist period in the Soviet Union and in Soviet Estonia [PDF]

Journal of Art Historiography, 2016
This article identifies a number of concepts that have been used in popular discourse on Baroque art, architecture and visual culture on both sides of the Iron Curtain.
Krista Kodres
doaj