Results 161 to 170 of about 538,969 (317)

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

How to co-create context-sensitive analyses of health service experiences: proposed guidelines for contextualist collaborative thematic analyses with co-researchers. [PDF]

Int J Qual Stud Health Well-being
Bahl NKH, Brodahl M, Nafstad HE, Blakar RM.   +3 more
europepmc   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

ANALYSIS OF APPROACHES TO THE ORGANIZATIONAL CULTURES TYPOLOGY IN CROSS-CULTURAL MANAGEMENT

Scientific opinion: Economics and Management, 2020
openaire   +1 more source

Developing a Virtual Reality Application for Social and Emotional Wellbeing and Cultural Determinants of Health Support With an Aboriginal Community of Sydney, New South Wales, Australia: Protocol for an Acceptability and Feasibility Study. [PDF]

JMIR Res Protoc
Garay J, Phillips S, Purdam J, Duczynski J, Azizi M, Dickson M, Carter M, Hespanhol L, Negin J, Mooney-Somers J.   +9 more
europepmc   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Mobile app for promoting cultural heritage: geostatistic and textual analysis

, 2019
This study presents an innovative technological solution, applied to the promotion of both tangible and intangible cultural heritage of the Salento territory (an Italian sub-peninsula).
Clara Renna, Laura Fortunato, Marco Lucio Sarcinella, Angelo Corallo, Alessandra Spennato, Cristina De Blasi   +5 more
core  

Exploring the Social and Cultural Influences on Advance Care Planning Engagement for Patients Living With Cancer: A Hermeneutic Phenomenology Study. [PDF]

Nurs Inq
Lin CP, Huang CY, Peng JK, Chang HT.
europepmc   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

<i>What Matters 2 Kids:</i> a mixed-methods protocol for developing a culturally-responsive illustrated well-being measure for Aboriginal and Torres Strait Islander children. [PDF]

BMJ Open
Anderson KM, Howard K, Dickson M, Gall A, Garvey D, Howell M, Theobald M, Mulhern BJ, Viney R, Garvey G.   +9 more
europepmc   +1 more source