Results 71 to 80 of about 129,793 (261)

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Which background factors matter more in intergenerational educational attainment: Social class, cultural capital or cognitive ability? A random effects approach [PDF]

The sociological research literature on intergenerational educational attainment has highlighted three types of theoretical frameworks in explaining to what extent social origins influences people’s educational choices and possibilities.
Anders Holm, Mads Meier Jæger
core  

Assessing the effect of culturally specific audiovisual educational interventions on attaining self-management skills for chronic obstructive pulmonary disease in Mandarin- and Cantonese-speaking patients: a randomized controlled trial

International Journal of COPD, 2016
Iraj Poureslami,1,2 Susan Kwan,3 Stephen Lam,4,5 Nadia A Khan,6,7 John Mark FitzGerald 8,9 1Respiratory Division, Department of Medicine, Faculty of Medicine, University of British Columbia, Vancouver, Canada; 2Department of Graduate ...
Poureslami I, Kwan S, Lam S, Khan NA, FitzGerald JM   +4 more
doaj  

Job Expectations of Millennials in Poland, Germany and Chile

Gospodarka Narodowa. The Polish Journal of Economics, 2018
Millennials are the first age cohort that grew up in an internationally connected world. Globalisation has seen the emergence of a global culture that affects national cultures.
Jacek Miroński, Małgorzata Gawlik
doaj   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Medicine in a multi-cultural society: the effect of cultural background on beliefs about medications

, 2004
This exploratory, cross-sectional study examined the effect of self-reported cultural background on beliefs about medicines (modern pharmaceuticals) and perceptions of personal sensitivity to the adverse effects of taking medication.
Hankins, M, Horne, R, Horne, R., Graupner, L, Hankins, M., Frost, S., Frost, S, Weinman, J, Weinman, J., Wright, S M, Graupner, L., Wright, S.M.   +11 more
core   +1 more source

Assessment of a Reading Comprehension Instrument as It Relates to Cognitive Abilities as Defined by Bloom's Revised Taxonomy

Current Issues in Education, 2014
More often than not, the assessment of literacy has focused upon how well readers attain various levels of reading comprehension or demonstrate proficiency with specific reading skills rather than reveal a reader’s cognitive abilities as reflected in ...
Lorraine Dagostino, James Carifio, Jennifer D. C. Bauer, Qing Zhao, Nor Hashimah Hashim   +4 more
doaj  

The Effects of Cultural Background and Past Usage on IranianAustralians’ Appreciation of Urban Parks and Aesthetic

Landscape Online, 2019
To understand how newcomers and established immigrants perceive cultural landscapes that have been imbued with a nationality’s cultural meanings and heritage, exploring the cultural background and landscape myths and values of that immigrants’ community
Nasim Yazdani
doaj   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source