Results 101 to 110 of about 940,270 (260)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Did local government structure kill small town America? [PDF]
This article examines the provision of public goods in an urban area and the effect voting has on the level and location of amenities throughout a city. It is particularly appropriate for small communities that must finance economic development projects ...
Warziniack, Travis
core +1 more source
Comments on Caddo Origins in Northwest Louisiana [PDF]
, 2009 This paper presents some of my thoughts on the issue of Caddo origins from the perspective of the Red River drainage in northwest Louisiana. These ideas were assembled prior to the Caddo discussion group meeting held in December 2008 and have been only ...
Girard, Jeffery S.
core +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Features of Granting Customs and Tax Privileges within the International Cultural Cooperation
Управленческое консультирование, 2018 The article analyzes the prisoners of the Russian Federation, international agreements on the functioning of the cultural centers of foreign States on the territory of the Russian Federation and the provision of cultural centers and their employees of ...
Mikhail Alekseevich Laboskin
doaj
Valuing Historic Places: Traditional and Contemporary Approaches [PDF]
, 2010 Decisions about which older buildings, structures, and places should be conserved are fundamental to the practice of architectural conservation. Conservation professionals use the interrelated concepts of integrity, authenticity, and historical value to ...
Wells, Jeremy C.
core +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Immigrant Youth and Digital Disparty in California [PDF]
, 2006 This study addresses three key research questions regarding immigrant youth and the digital divide:What are the patterns of home technology use among native-born and immigrant families and youth?What are the causes and consequences of the digital divide ...
Rob Fairlie
core
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source