Results 111 to 120 of about 4,594,987 (303)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Necessity of Monitoring and Cultural Training in Infertility Treatment Centers
Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Shahīd Ṣadūqī Yazd, 2020 Introduction: Lifestyle is one of the important factors of public health and reproductive health that is considered as the result of interaction between individual characteristics, environmental conditions and social class.
Javad Tavakoli Bazzaz +2 more
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Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
جامعه شناسی کاربردی, 2011 The paper studies sufficiency and capability of cultural and artistic centers, as university's civil institutions, for developing social capital. According to Putnam's approach, the research analyses the triple forms of social capital, Within-centers ...
Hamed Shiri, Abolfazl Morshedi
doaj
Cultural Competency in Haitian-Serving Community Health Centers in South Florida
McGill Journal of Medicine, 2020 The purpose of this research was to explore the perspectives of health care administrators, practitioners and patients regarding the role and operationalization of cultural competency in their organizations.
David Campbell
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Arhitektonsko-graditeljsko i kulturno istorijsko naslede Polimlja, od tradicionalnog do modernog - zbornik radovaThe intention is to get to know the construction of the Prijepolje cultural center more closely, which we are convinced has a special place in the rich production of Professor Ilić, an architect whose work has not been researched so far. The research was conducted through direct theoretical observations, available technical and photographic ...
openaire +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
LEVEL OF PHYSICAL ACTIVITY OF WOMEN AND MEN FROM INDEPENDENT CULTURAL CENTERS IN POLAND
Health Problems of Civilization, 2021 Michał Bergier, Barbara Bergier
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