Results 141 to 150 of about 845,812 (331)
Loss of proton‐sensing GPR4 reduces tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.G protein‐coupled receptor 4 (GPR4) is a pH‐sensing receptor activated by acidic pH. GPR4 expression is increased in patients with inflammatory bowel disease who are at high risk of developing colorectal cancer. In mouse models, loss of GPR4 attenuated tumor progression. This correlated with increased IL2 and natural killer cell activity.
Leonie Perren +16 more
wiley +1 more source
The Museums Network Model of the Piraeus Bank Group Cultural Foundation [PDF]
The Piraeus Bank Cultural Foundation (P.I.O.P) aims in rescuing, recording and promoting the heritage and cultural identity of Greece. Within this framework it organises and manages a network of thematic museums, which are continuously expanding in the ...
Elia Vlachou, Stella Demestiha
core
On Occasion of the 9th Anniversary of the Inter-American Development Bank Cultural Center: Art of the Americas [PDF]
, 2001 openalex +1 more source
TRPM8 levels determine tumor vulnerability to channel agonists
Molecular Oncology, EarlyView.TRPM8 is a Ca2+ permissive channel. Regardless of the amount of its transcript, high levels of TRPM8 protein mark different tumors, including prostate, breast, colorectal, and lung carcinomas. Targeting TRPM8 with channel agonists stimulates inward calcium currents followed by emptying of cytosolic Ca2+ stores in cancer cells.
Alessandro Alaimo +18 more
wiley +1 more source
Editorial: Food System Dynamics [PDF]
The food system involves all actors, activities, resources, and environments that produce and provide food to people wherever they are. It serves basic human needs and is as such of core relevance for human survival.
Fritz, Melanie, Schiefer, Gerhard
core +1 more source
Molecular Oncology, EarlyView.The pan‐HDAC inhibitor belinostat increases the expression of the pro‐apoptotic proteins Bim, Puma, and Noxa and induces apoptosis in ovarian cancer cell lines and patient‐derived tumor organoids when used at high concentrations. Moreover, inhibiting the anti‐apoptotic proteins Bcl‐xL or Mcl‐1 sensitizes these preclinical models to the cytotoxic effect
Cécilia Thomine +10 more
wiley +1 more source
Architecture of tourist visit centers: domestic and foreign experiences
АрхитектонThe patterns of transformation of tourist centers (TC) into tourist visiting centers (V-Ts) are considered. Differences in interests between tourists (socio-cultural) and travel agencies (economic) are outlined.
Bazilevich Anatoly M.
doaj +1 more source