Results 81 to 90 of about 845,812 (331)

Preservation Strategies of the Cultural Heritage of the Historical Centers of Puebla, Havana and Quito

open access: yesRevista de Estudios Andaluces, 2020
This research is based on a descriptive methodology regarding the main urban-architectural typological characteristics of the historic cities of Puebla, Havana and Quito, emphasizing current legislation and conservation policies for their protection ...
Norma Leticia Ramírez-Rosete   +2 more
doaj  

Insights into pegRNA design from editing of the cardiomyopathy‐associated phospholamban R14del mutation

open access: yesFEBS Letters, EarlyView.
This study reveals how prime editing guide RNA (pegRNA) secondary structure and reverse transcriptase template length affect prime editing efficiency in correcting the phospholamban R14del cardiomyopathy‐associated mutation. Insights support the design of structurally optimized enhanced pegRNAs for precise gene therapy.
Bing Yao   +7 more
wiley   +1 more source

Tutor Handbooks: Heuristic Texts for Negotiating Difference in a Globalized World [PDF]

open access: yes, 2012
I would like to begin this article by telling a true story. When I was a graduate student earning my doctoral degree, I worked in a writing center on a midsized and predominantly white university campus.
Bailey, Steven K.
core   +1 more source

Intron‐oriented HTLV‐1 integration in an adult T‐cell leukemia/lymphoma cell line sustains expression of intact ift81 mRNA

open access: yesFEBS Letters, EarlyView.
In the adult T‐cell leukemia/lymphoma (ATL) cell line ED, the human T‐cell leukemia virus type 1 (HTLV‐1) provirus was integrated into the intron of the ift81 gene in the antisense orientation. Despite this integration, both the intact ift81 and the viral oncogene hbz were simultaneously expressed, likely due to the functional insufficiency of viral ...
Mayuko Yagi   +5 more
wiley   +1 more source

Social Change and Criminality in Istanbul [PDF]

open access: yes
Many researchers and urban planners have made studies about security in city centers. One of the prerequisites for the continuous development of cities is to establish a safe environment.
Cengiz Giritlioglu   +2 more
core  

Approaching Evaluation in Youth Community Informatics [PDF]

open access: yes, 2009
In the Youth Community Informatics project, young people from disadvantaged communities use audio and video recording and editing tools, GPS/GIS, presentation software, graphics, and other digital technologies as the means for addressing community needs.
Bruce, Bertram C.   +2 more
core  

Cyclic nucleotide signaling as a drug target in retinitis pigmentosa

open access: yesFEBS Letters, EarlyView.
Disruptions in cGMP and cAMP signaling can contribute to retinal dysfunction and photoreceptor loss in retinitis pigmentosa. This perspective examines the mechanisms and evaluates emerging evidence on targeting these pathways as a potential therapeutic strategy to slow or prevent retinal degeneration.
Katri Vainionpää   +2 more
wiley   +1 more source

Survey data on users perception of flexibility of spaces in selected cultural center in southwest Nigeria

open access: yesData in Brief, 2018
Architects that specialize in designing cultural centers have often been accused of providing spaces that become obsolete in the coming years. This is because as technology and time changes, requirements also change, necessitating new arrangement of ...
Adedapo Oluwatayo   +11 more
doaj  

Buchi Emecheta : A Novelist\u27s Image of Nigerian Women [PDF]

open access: yes, 1991
Nigerian novelist Buchi Emecheta writes about the lives of twentieth century Nigerian women. Living during the post-World War II decades of British colonialism, and the subsequent move towards Nigerian Independence in the 1950s, Emecheta\u27s women are ...
Ellsworth, Kirstin Lynne
core   +1 more source

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