Results 81 to 90 of about 140,997 (296)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Features of Granting Customs and Tax Privileges within the International Cultural Cooperation

open access: yesУправленческое консультирование, 2018
The article analyzes the prisoners of the Russian Federation, international agreements on the functioning of the cultural centers of foreign States on the territory of the Russian Federation and the provision of cultural centers and their employees of ...
Mikhail Alekseevich Laboskin
doaj  

Cell density–dependent nuclear‐cytoplasmic shuttling of SETDB1 integrates with Hippo signaling to regulate YAP1‐mediated transcription

open access: yesFEBS Letters, EarlyView.
At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom   +3 more
wiley   +1 more source

Culture center+ Torshälla

open access: yes, 2022
A culture center och the close community connected is an infrastructure that contributes to the social landscape in the area. The architecture of the building is a resource helps manifest conditions that connect people. The culture center is a practical and symbolic gesture that makes this visual.
openaire   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Cultural and artistic centers and developing social capital (The study of social capital forms in the cultural and artistic centers of Tehran\\\'s universities)

open access: yesجامعه شناسی کاربردی, 2011
The paper studies sufficiency and capability of cultural and artistic centers, as university's civil institutions, for developing social capital. According to Putnam's approach, the research analyses the triple forms of social capital, Within-centers ...
Hamed Shiri, Abolfazl Morshedi
doaj  

Necessity of Monitoring and Cultural Training in Infertility Treatment Centers

open access: yesMajallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Shahīd Ṣadūqī Yazd, 2020
Introduction: Lifestyle is one of the important factors of public health and reproductive health that is considered as the result of interaction between individual characteristics, environmental conditions and social class.
Javad Tavakoli Bazzaz   +2 more
doaj  

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

open access: yesMolecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero   +8 more
wiley   +1 more source

Cultural Competency in Haitian-Serving Community Health Centers in South Florida

open access: yesMcGill Journal of Medicine, 2020
The purpose of this research was to explore the perspectives of health care administrators, practitioners and patients regarding the role and operationalization of cultural competency in their organizations.
David Campbell
doaj  

Home - About - Disclaimer - Privacy