Results 121 to 130 of about 6,240,707 (340)
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Визуальная теологияThe traditional Russian city is not only a rationally planned place of habitation, providing its inhabitants with safety and realization of utilitarian needs, but also a work of urban art, embodying the basic principles of axiologically coloured ...
Sergey Avanesov / Сергей Сергеевич Аванесов
doaj +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Innovative collaborative design in international interaction design summer schools [PDF]
, 2009 [About the book]: Design is changing, and to educate the next generation of designers, these changes need to be addressed. In light of the growing role research and interdisciplinary collaboration play in contemporary design performance, Design ...
Schadewitz, Nicole
core
Semiotic Analysis of Characteristic Image of Jogja Society in the Film of “Jagad X-Code” [PDF]
, 2010 The object of the research is the film of Jagad X-Code. The film of Jagad X-Code took DI Yogyakarta as the setting of this film. The people of Jogja maintain the strong characteristic of Java which is represented in this comedy film.
Herawati, H. (Herawati)
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Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer
Molecular Oncology, EarlyView.PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta +10 more
wiley +1 more source
Studia Humanitatis, 2018 The article describes the creative heritage of Dmitry Merezhkovsky through the lens of identifying and functioning of cultural signs. The relevance of the proposed topic is related to the fact that the semantic limit of the literary text lies precisely ...
Bezrukov Andrei Nikolayevich
doaj
Frame-Scenario in the Representation of Literary Fiction: Linguocultural Insights
Ученые записки Казанского университета: Серия Гуманитарные наукиThe role of the frame-scenario as a cognitive structure within the artistic image, a key element of literary fiction, was studied. By examining Agatha Christie’s novel “A Pocket Full of Rye”, an example of detective discourse, the linguocultural and ...
A. I. Dzyubenko
doaj +1 more source