Results 61 to 70 of about 116,809 (305)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Cultural competence and the higher education sector: A journey in the academy
, 2020 © The Author(s) 2020. Although cultural competence in higher education is a worthwhile starting point for teaching, learning, research and leadership in the higher education sector, it has been argued that it is the journey and not the destination that ...
Frawley, J +5 more
core +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Towards an Enterprises’ Cross-Cultural Competence Scale
SAGE OpenEnterprises engaged in international business have been playing a crucial role in international business arena and their cross-cultural competence, as a type of dynamic capability, is indispensible.
Jing Jiao +3 more
doaj +1 more source
Curiosity and its role in cross-cultural knowledge creation [PDF]
, 2016 This paper explores the role of curiosity in promoting cross-cultural knowledge creation and competence development. It is based on a study with four international higher educational institutions, all of which offer management and business education ...
Natalie S. Mikhaylov +1 more
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Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Development of human monoclonal antibodies against TARM1 by yeast display
FEBS Open Bio, EarlyView.Human monoclonal antibodies against TARM1 are generated by yeast display‐guided selection. These antibodies bind to soluble and cell‐surface forms of TARM1. Also, these antibodies exhibit agonistic activity in the NFAT‐GFP reporter assay, indicating that TARM1 signaling can be functionally modulated by antibodies and suggesting TARM1 as a potential ...
Rikio Yabe +5 more
wiley +1 more source
A virtual training program for improving cultural competence among academic nurse educators
BMC Medical Education, 2023 Background Everyday, nursing students interact with culturally diverse clients. Nursing education recognizes that cultural competence is a necessary outcome of nursing programs.
Monireh Rahimi +3 more
doaj +1 more source
Rethinking cultural competence [PDF]
Transcultural Psychiatry, 2012 In recent years, cultural competence has become a popular term for a variety ofstrategies to address the challenge of cultural diversity in mental health services.This issue of Transcultural Psychiatry presents papers from the McGill AdvancedStudy Institute in Cultural Psychiatry on ‘‘Rethinking Cultural Competencefrom International Perspectives ...
openaire +2 more sources
Cultural competency in the delivery of health services for Indigenous people [PDF]
, 2015 Aim and objectives This review aims to examine available evidence on cultural competence in health care settings to identify key approaches and strategies that can contribute to improving the development and implementation of Indigenous health services ...
K Tsey (9849185) +15 more
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