Results 41 to 50 of about 1,066,703 (287)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Cultural consumption and souvenirs: an ethical framework [PDF]

, 2012
The purpose of this paper is to propose guidelines for business enterprises engaging with indigenous communities to protect their intellectual property rights, particularly indigenous art works produced for the souvenir ...
Brennan, L, Savage, T
core   +2 more sources

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Cultural vouchers as a tool for stimulating cultural consumption and spiritual and moral development of youth and children

Informaciâ i Innovacii, 2022
In order to stimulate the spiritual and moral development of youth and children in many countries, a relatively new tool was used – a cultural voucher, which is the subject of this study. The purpose of the article is to identify the features of cultural
M. S. Ciobanu
doaj   +1 more source

Taste and the algorithm [PDF]

, 2018
Today, a consistent part of our everyday interaction with art and aesthetic artefacts occurs through digital media, and our preferences and choices are systematically tracked and analyzed by algorithms in ways that are far from transparent.
Arielli, Emanuele
core   +1 more source

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

Cultural Mobilization During the Special Military Operation: How “New” Ethics Changes “Old” Habits

Регионология
Introduction. In Russia, after the start of the Special Military Operation in Ukraine, large-scale transformations accelerated, affecting all spheres of activity, including cultural consumption practices.
Natalia V. Zhadunova, Ekaterina A. Koval, Sergey G. Ushkin, Andrey A. Sychev   +3 more
doaj   +1 more source

The attitude-behavior relationship in the domain of cultural consumption: A case of museums' festivals [PDF]

Sociološki Pregled, 2017
In this paper, comparative analysis of two research studies about museum festivals' audience is presented (Museum Night 2012, N = 1480, and Museums of Serbia 2016, N = 2472).
Jokić Biljana, Mrđa Slobodan
doaj   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

Músicos, productores y audiencias, cercanía desde la mediación social y tecnológica en Colombia

Les Cahiers ALHIM, 2018
Music is one of the cultural and creative industries that has changed the most owing to the technologies of information and communication (ICT). News about the death of this industry, the concentration of majors, copyright problems, download platforms ...
Sandra Velásquez, Tatiana López, Fabián Valverde   +2 more
doaj   +1 more source