Results 61 to 70 of about 5,572,091 (300)

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

open access: yesMolecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu   +3 more
wiley   +1 more source

Analyzing cultural routes from a multidimensional perspective

open access: yesAlmatourism, 2011
The objective of this work is to examine cultural routes from a multidimensional and hence a multidisciplinary perspective. Economic impacts and geographical sides are the most studied aspects.
Wided Majdoub
doaj   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

open access: yesMolecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico   +5 more
wiley   +1 more source

Cultural values and cross-cultural video consumption on YouTube

open access: yesPLOS ONE, 2017
Video-sharing social media like YouTube provide access to diverse cultural products from all over the world, making it possible to test theories that the Web facilitates global cultural convergence. Drawing on a daily listing of YouTube's most popular videos across 58 countries, we investigate the consumption of popular videos in countries that differ ...
Minsu Park   +3 more
openaire   +6 more sources

Bridging the gap: a genetically validated avian chorioallantoic membrane platform for investigation of spontaneous circulating tumor cells

open access: yesMolecular Oncology, EarlyView.
We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth   +17 more
wiley   +1 more source

Consuming the nation. Domestic cultural consumption: its stratification and relation with nationalist attitudes [PDF]

open access: yes, 2014
This dissertation addressed people’s domestic versus foreign cultural consumption. In many countries, including the Netherlands which is the main focus of this dissertation, a large share of the cultural goods people consume originates from foreign ...
Afd Interdisciplinaire Sociale Wetensch.   +3 more
core   +2 more sources

Beyond Escapism: The Positive Role of Cosplay in Gender Expression, Mental Health, and Cultural Consumption in Japan

open access: yesSocial Sciences
With the promotion and development of anime, manga, and video games in Japan and beyond, a substantial number of fans have been attracted. These people began to dress up as their favorite characters.
Moqiao Liu
doaj   +1 more source

Factors Affecting Attitudes towards Cohabitation among Iranian Youth [PDF]

open access: yesجامعه شناسی کاربردی
Introduction In previous decades, marriage has been more prevalent, while cohabitation has been largely limited to specific social groups. However, attitudes toward cohabitation are shifting in many countries, resulting in its increased acceptance and ...
Reyhane Ghasemi Neyasar   +2 more
doaj   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

open access: yesFEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz   +6 more
wiley   +1 more source

Social Status and Cultural Consumption

open access: yes, 2010
How does cultural hierarchy relate to social hierarchy? Do the more advantaged consume 'high' culture, while the less advantaged consume popular culture? Or has cultural consumption in contemporary societies become individualised to such a degree that there is no longer any social basis for cultural consumption?
Chan, T   +11 more
openaire   +1 more source

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