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Cultural Barriers and Agricultural Trade in the Western Hemisphere [PDF]
This study analyzes the impacts of cultural distance on bilateral trade flows in the Western Hemisphere using a Fixed Effects Vector Decomposition (FEVD). Four cultural dimensions of Hofstede are used to capture cultural distance.
Rosson, C. Parr, III, Susanto, Dwi
core +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Illicit Trade and Hofstede’s Cultural Dimensions
Economics and Culture, 2020 Research purpose. Growth of illicit trade has markedly increased and caused damage to a multitude of economic, socio-economic and environmental outcomes.
DiRienzo Cassandra E., Das Jayoti
doaj +1 more source
We're on a road to nowhere... new forms of work organization and national cultures [PDF]
The main objective of this paper is to discuss how far the cultural environment is related to the potential that new forms of work organization, namely autonomy and teamwork, have for success. To accomplish this objective two main approaches will be used:
Ferreira, Pedro
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Why anthropocentric organization models don't succeed in Portugal? A cultural perspective using Hofstede's cultural dimensions [PDF]
, 2008 In Europe, anthropocentric organization models – an updated version of the sociotechnique approach – had their maximum expression in the Swedish model, which came to be known as “uddevalism” or “volvoism”.
Ferreira, Pedro
core
Cultures in Community Question Answering
, 2015 CQA services are collaborative platforms where users ask and answer questions. We investigate the influence of national culture on people's online questioning and answering behavior.
Bonchi, Francesco +4 more
core +1 more source