Results 51 to 60 of about 1,519,941 (288)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Cultural dimensions and CRM systems: a structurational analysis [PDF]

open access: yes, 2008
Cultural dimensions are often identified as a crucial influence on the success or failure of Information Systems in general and Customer Relationship Management Systems (CRM) in particular.
Ali, M, Alshawi, S, Brooks, L
core  

Carrying Cultural Baggage: the contribution of socio-cultural anthropology to cross-cultural coaching [PDF]

open access: yesInternational Journal of Evidence Based Coaching and Mentoring, 2007
This study examines the cultural awareness of professionals working in organisations. Given the multicultural nature of today’s workforce, it is becoming increasingly important for companies and coaches alike to take into account how cross-cultural ...
Barbara St Claire-Ostwald
doaj  

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

The different dimensions of livelihood impacts of Payments for Environmentals Services (PES) schemes: A systematic review [PDF]

open access: yes, 2018
Through a systematic review of peer-reviewed and grey literature, this paper analyzes evidence of the livelihood impacts of Payments for Environmental Services (PES). Forty-six studies assessed PES livelihood impacts.
Bax, Vincent   +5 more
core   +7 more sources

Conclusion: Directions for Research in Online Learning Cultures [PDF]

open access: yes, 2009
In this chapter, the authors review issues currently under-represented in research on the cultural dimensions of e-learning, such as the institutional cultural hegemony over pedagogy that is enjoyed by Westernized constructions of learning and teaching ...
Goodfellow, Robin, Lamy, Marie-Noelle
core  

Best HRM Practices or Context-Specific HRM Practices: Evidence from the Telecommunications Sector of Pakistan

open access: yesJournal of Management and Research
The current study attempted to explore the idea of convergence versus divergence of best Human Resource Management (HRM) practices in the context of Pakistan. In recent years, the businesses of multinational companies have grown immensely. This, in turn,
Farwa Abbas   +2 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

THE DIMENSIONS OF CORPORATE AND NATIONAL CULTURE: THE CROSS-NATIONAL ANALYSIS [PDF]

open access: yesEconomica, 2017
Corporate culture has a strong impact on the operation of an economic unit. National culture is one of the factors, which determines the characteristics of corporate culture.
Lilia COVAS, Angela PIRLOG
doaj  

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

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