Results 71 to 80 of about 150,301 (247)

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

open access: yesMolecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone   +11 more
wiley   +1 more source

POLITENESS: CULTURAL DIMENSIONS OF LINGUISTIC CHOICE

open access: yesIJEE (Indonesian Journal of English Education), 2018
Language has a social function to make connection between human beings. Without language, people seem to be impossible to interact with others in their daily communication.
Fitriah Fitriah, Didin Nuruddin Hidayat
doaj   +1 more source

Hofstedes Cultural Dimensions

open access: yes, 2013
Geert Hofstede’s seminal 1980 book, Culture’s Consequences: International Differences in Work-Related Values, along with its 2001 reissue and expansion and related journal articles, is without question the most influential work on culture in the field of international management.
openaire   +1 more source

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

open access: yesMolecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg   +43 more
wiley   +1 more source

Hofstede’s Cultural dimensions in Ecuadorian society

open access: yesAmauta, 2018
The present article makes an important tour of the concept of culture. It focuses on the theory of the Dutch anthropologist Geert Hendrik Hofstede, who states that the cultural groupings that a society has influence their behavior and decision making in ...
Iliana Aguilar Rodríguez   +4 more
doaj   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon   +13 more
wiley   +1 more source

SPEZIFIZITÄT VS. DIFFUSITÄT IN DER RUMÄNISCHEN UND IN DER DEUTSCHEN WERBUNG / THE DIMENSION SPECIFIC VS. DIFFUSE IN ROMANIAN AND GERMAN ADVERTISING [PDF]

open access: yesJournal of Languages for Specific Purposes, 2019
The dimension specific vs. diffuse means that in specific cultures the areas of life are clearly separated and encounters with other people are also considered in these categories.
Patrick Lavrits
doaj  

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