Results 81 to 90 of about 1,701,532 (293)

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

open access: yesFEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga   +3 more
wiley   +1 more source

Everyday Diversity

open access: yesCosmopolitan Civil Societies: An Interdisciplinary Journal, 2015
The Cosmopolitan Civil Societies Journal has been an important forum for discussing issues around cultural diversity. Articles on cultural diversity have been present in virtually every issue of the journal.
Christina Ho
doaj   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

open access: yesMolecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra   +10 more
wiley   +1 more source

Cultural Intelligence as a Prism between Workforce Diversity and Performance in a Modern Organization [PDF]

open access: yes
In today’s globalizing world it is of importance for managers to manage the constantly growing workforce diversity. Besides the generally promoted idea of diversity management, often limited to fair employment, less attention has been paid to the ...
Kadri KARMA, Rebekka VEDINA
core  

The impact of cultural diversity on firm innovation: evidence from Dutch micro-data [PDF]

open access: yes, 2013
An important question for firms and policy makers is whether the recruitment of foreign workers can boost innovation. Migration studies have demonstrated positive economic impacts of cultural diversity on productivity and innovation at the regional level,
Nijkamp, Peter   +2 more
core   +2 more sources

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

open access: yesMolecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice   +16 more
wiley   +1 more source

Diversidade cultural e cosmopolitismo Cultural diversity and cosmopolitism

open access: yesLua Nova: Revista de Cultura e Política, 1999
Num mundo globalizado a diversidade cultural deve ser pensada de um ponto de vista cosmopolita. Somente uma visão universalista pode valorizar realmente o que denominamos "diferença".In a globalized world cultural diversity should be conceived from a ...
Renato Ortiz
doaj   +1 more source

Migration and Innovation - Does Cultural Diversity Matter for Regional R&D Activity? [PDF]

open access: yes
Recent theoretical research deals with economic costs and benefits of cultural diversity related to immigration. Empirical evidence regarding the impact of cultural diversity on economic performance is still scarce.
Annekatrin Niebuhr
core  

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

open access: yesMolecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak   +4 more
wiley   +1 more source

Emotional responses of Korean and Chinese women to Hangul phonemes to the gender of an artificial intelligence voice

open access: yesFrontiers in Psychology
IntroductionThis study aimed to explore the arousal and valence that people experience in response to Hangul phonemes based on the gender of an AI speaker through comparison with Korean and Chinese cultures.MethodsTo achieve this, 42 Hangul phonemes were
Min-Sun Lee   +3 more
doaj   +1 more source

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