Results 91 to 100 of about 1,701,532 (293)
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Editorial. Design and Cultural Diversity
FORMakademisk, 2019 By raising the theme of Design and Cultural Diversity in this special issue of FormAkademisk we hope to stimulate a broad cross disciplinary discussion on the interplay of cultures within the field of design and design education.
Astrid Skjerven
doaj +1 more source
A focus on getting along: respect, caring and diversity [PDF]
, 2016 Drawing inspiration om Joseph T. O’Connell’s work on socio‐cultural integration, this pa‐ per connects the notion of ‘deep equality’ with two broad lessons that can be taken om O’Connell’s approach that pertain to the study of religious diversity in ...
Beaman, Lori G.
core +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Cultural Diversity and Local Labour Markets [PDF]
During the last decade there have been marked changes in the composition of the non-native workforce in the German labour market. In particular there has been a notable increase in the diversity of nationalities of which the foreign workforce is composed.
Blien, Uwe, Suedekum, Jens, Wolf, Katja
core
Cities and Cultural Diversity: Facts – Positions – Strategies. BertelsmannStiftung Studies [PDF]
, 2018 This study presents the current state of research and debates on migration-driven diversity and how it is addressed in German cities. It also articulates the various positions taken in these approaches.
Alpermann, Hendrijke +1 more
core
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Cultural Diversity and Economic Growth: Evidence from the US during the Age of Mass Migration [PDF]
We exploit the large inflow of immigrants to the US during the 1870-1920 period to examine the effects that changes in the cultural composition of the population of US counties had on output growth.
Markus Bruckner, Philipp Ager
core
Molecular Oncology, EarlyView.Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source