Results 91 to 100 of about 292,537 (301)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Diversidade cultural e cosmopolitismo Cultural diversity and cosmopolitism

Lua Nova: Revista de Cultura e Política, 1999
Num mundo globalizado a diversidade cultural deve ser pensada de um ponto de vista cosmopolita. Somente uma visão universalista pode valorizar realmente o que denominamos "diferença".In a globalized world cultural diversity should be conceived from a ...
Renato Ortiz
doaj   +1 more source

Cultural Diversity A Glimpse Over the Current Debate in Sweden [PDF]

A year and a half ago, the Swedish government decided 2006 to be The Year for Cultural Diversity (Agenda för Mångkultur, 2005). The general purpose, according to the directive, is to facilitate the possibilities for all citizens to participate in all ...
Kiflemariam Hamde
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Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Emotional responses of Korean and Chinese women to Hangul phonemes to the gender of an artificial intelligence voice

Frontiers in Psychology
IntroductionThis study aimed to explore the arousal and valence that people experience in response to Hangul phonemes based on the gender of an AI speaker through comparison with Korean and Chinese cultures.MethodsTo achieve this, 42 Hangul phonemes were
Min-Sun Lee, Gi-Eun Lee, San Ho Lee, Jang-Han Lee   +3 more
doaj   +1 more source

Office of Cultural Diversity Annual Report (2014-2015)

, 2015
University of Minnesota Duluth. Office of Cultural Diversity. (2015). Office of Cultural Diversity Annual Report (2014-2015).
University of Minnesota Duluth. Office of Cultural Diversity
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CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Editorial. Design and Cultural Diversity

FORMakademisk, 2019
By raising the theme of  Design and Cultural Diversity in this special issue of FormAkademisk we hope to stimulate a broad cross disciplinary discussion on the interplay of cultures within the field of design and design education.
Astrid Skjerven
doaj   +1 more source

Office of Cultural Diversity Strategic Plan (2014-2015)

, 2014
University of Minnesota Duluth. Office of Cultural Diversity. (2014). Office of Cultural Diversity Strategic Plan (2014-2015).
University of Minnesota Duluth. Office of Cultural Diversity
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Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source