Results 111 to 120 of about 292,537 (301)
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Migration and innovation: Does cultural diversity matter for regional R&D activity? [PDF]
"Recent theoretical research deals with economic costs and benefits of cultural diversity related to immigration. However, empirical evidence regarding the impact of cultural diversity on economic performance is still scarce.
Niebuhr, Annekatrin
core +2 more sources
"Cultural diversity” at UNESCO : a trajectory
, 2015 This itinerary has been based principally on an understanding of “cultural diversity” as denoting cultural differences among nations rather than within them.
Isar, Yudhishthir Raj (R17409) +1 more
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Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
THE EVOLUTION OF CULTURAL DIVERSITY: A PHYLOGENETIC APPROACH
, 2005 Preface -- About the contributors -- 1. Introduction: a phylogenetic approach to the evolution of cultural diversity / Ruth Mace -- Pt. I. -- 2. Introduction to part I: how tree-like is cultural evolution? / Clare J. Holden and Stephen Shennan -- 3.
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MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
09 Cultural Diversity and the Culture of Diversity in Education
International Journal of Social and Educational Innovation, 2014 The presence of „the difference” in education is a fact sustained by the meeting between educational actors, in terms of negotiation on individual and social values. Therefore learning experiences offered to students have to be constructed in a multifaceted manner.
openaire +1 more source
Promoting diversity of cultural expression in arts in Australia: a case study report
, 2015 This report is an outcome of a Memorandum of Understanding between the Australia Council and the United Nations Educational, Scientific and Cultural Organisation (UNSECO) Bangkok to promote cultural diversity in the Asia-Pacific, signed in 2012.
Phillip Mar +3 more
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Cultural diversity: impact on the doctoral candidate-supervisor relationship [PDF]
, 2012 A number of aspects influencing the relationship between the doctoral candidate and the supervisor have been identified as impacting on the success of postgraduate research supervision, but the influence of the cultural diversity of doctoral candidates ...
Erwee, Ronel +3 more
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Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source