Results 91 to 100 of about 486,447 (257)

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

open access: yesMolecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault   +12 more
wiley   +1 more source

Bridging the gap: a genetically validated avian chorioallantoic membrane platform for investigation of spontaneous circulating tumor cells

open access: yesMolecular Oncology, EarlyView.
We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth   +17 more
wiley   +1 more source

Literary work and its audience

open access: yesRasprave Instituta za Hrvatski Jezik i Jezikoslovlje, 2011
The study of functions of German language elements, primarily separate words (lexical elements) and fixed expressions, proves that they are an integral part of the text, play a specific role in communication and illustrate a variety of contexts within a ...
István Nyomárkay
doaj  

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim   +17 more
wiley   +1 more source

Beyond entertainment: the role of film education in cultivating moral values among Chinese students

open access: yesCogent Arts & Humanities
This study explores how film education transcends entertainment to cultivate moral values among high school students in Shaanxi Province, China. Drawing on Bandura’s Social Learning Theory, the research examines how films serve as moral texts that invite
Weiyu Chen   +2 more
doaj   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

open access: yesFEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz   +6 more
wiley   +1 more source

The saturation effect of blended pedagogy on international students’ acculturation in Confucian classrooms

open access: yesFrontiers in Psychology
Blended pedagogy, combining lectures and practice, is widely adopted in cultural education, with the expectation that combining multiple pedagogies leads to better cross-cultural adaptation.
Hong Zhang   +7 more
doaj   +1 more source

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