Results 81 to 90 of about 464,088 (258)

Exploring Cultural Education and Economic Influences on People’s Well-being: Voices from Indonesia

Educational Process: International Journal
Background/purpose. This study aims to explore how cultural and economic factors shape the welfare of salt-farming communities in Madura, Indonesia. It highlights the importance of integrating local knowledge and cultural contexts into welfare policies,
Syamsul Arifin, Fulgentius Danardana Murwani, Imam Mukhlis, Agung Winarno   +3 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Enhancing Early Childhood Creativity through Project-Based Learning: Indonesian Traditions at KJRI Penang

Lectura: Jurnal Pendidikan
Project-Based Learning (PjBL) has been recognized for its potential to enhance various skills, including creativity, among learners. However, its impact on early childhood creativity, particularly within specific cultural contexts, remains underexplored.
Wahyu Dwi Saputri, Ardhana Januar Mahardani, Betty Yulia Wulansari   +2 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Development of ULOS Learning Model with AR to Foster Cultural Appreciation

Aptisi Transactions on Technopreneurship
Indonesia is rich in diverse cultural heritage, including the traditional ULOS cloth from North Sumatra. To preserve and appreciate local culture, it is essential for student teachers to develop a deep understanding and love for that culture.
Apriani Sijabat, Festiyed Festiyed, Abdul Razak, Skunda Diliarosta, Lufri Lufri, Natasha Leonie   +5 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Community-Based Non-Formal Education to Prevent Juvenile Delinquency: A Case Study of Rumah Pintar Kokoda in West Papua

Jurnal Pendidikan Islam
Purpose – This study explores the implementation and impact of the Rumah Pintar (Smart House) initiative in Kokoda, West Papua, which aims to address juvenile delinquency through community-based non-formal education.
Maemonah Maemonah, Sari Hernawati, Ruchman Basori, Jenro P. Sijabat   +3 more
doaj   +1 more source

Introducing cross-cultural education in palliative care: focus groups with experts on practical strategies. [PDF]

BMC Palliat Care, 2020
Semlali I, Tamches E, Singy P, Weber O.
europepmc   +1 more source