Results 81 to 90 of about 486,447 (257)

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Enhancing Early Childhood Creativity through Project-Based Learning: Indonesian Traditions at KJRI Penang

Lectura: Jurnal Pendidikan
Project-Based Learning (PjBL) has been recognized for its potential to enhance various skills, including creativity, among learners. However, its impact on early childhood creativity, particularly within specific cultural contexts, remains underexplored.
Wahyu Dwi Saputri, Ardhana Januar Mahardani, Betty Yulia Wulansari   +2 more
doaj   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Development of ULOS Learning Model with AR to Foster Cultural Appreciation

Aptisi Transactions on Technopreneurship
Indonesia is rich in diverse cultural heritage, including the traditional ULOS cloth from North Sumatra. To preserve and appreciate local culture, it is essential for student teachers to develop a deep understanding and love for that culture.
Apriani Sijabat, Festiyed Festiyed, Abdul Razak, Skunda Diliarosta, Lufri Lufri, Natasha Leonie   +5 more
doaj   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Exploring Cultural Education and Economic Influences on People’s Well-being: Voices from Indonesia

Educational Process: International Journal
Background/purpose. This study aims to explore how cultural and economic factors shape the welfare of salt-farming communities in Madura, Indonesia. It highlights the importance of integrating local knowledge and cultural contexts into welfare policies,
Syamsul Arifin, Fulgentius Danardana Murwani, Imam Mukhlis, Agung Winarno   +3 more
doaj   +1 more source

Community-Based Non-Formal Education to Prevent Juvenile Delinquency: A Case Study of Rumah Pintar Kokoda in West Papua

Jurnal Pendidikan Islam
Purpose – This study explores the implementation and impact of the Rumah Pintar (Smart House) initiative in Kokoda, West Papua, which aims to address juvenile delinquency through community-based non-formal education.
Maemonah Maemonah, Sari Hernawati, Ruchman Basori, Jenro P. Sijabat   +3 more
doaj   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Leveraging digitalization in geoheritage and geoparks: Analysis of advancements and trends through bibliometric analysis and the antecedents, decisions, outcomes-theories, contexts, methods (ADO-TCM) framework

International Journal of Geoheritage and Parks
This study aims to systematically analyze the role and trends of digitalization in geoheritage and geopark management, identifying research gaps and future opportunities to support sustainable development and policy-making.
Jessica Hermawan, Liliana Inggrit Wijaya, Andri Rianawati   +2 more
doaj   +1 more source