Results 61 to 70 of about 768,673 (305)

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Candle Symbolisms in the Sinulog Dance Vis-à-vis the Exploration of the Kahayag Model of Reflective Teaching

Diversitas Journal
Understanding the symbolism of candles in the Sinulog dance is essential to the devotional practices of Catholic Christians. The study described the symbolism of candles in the Sinulog dance, explored how this tradition continued, and examined potential
Erica Marie Aray, Lynvir Baltazar, Rhyca Jianne Avila, Reynaldo Inocian, Spencer Reyes   +4 more
doaj   +1 more source

Kurikulum Pendidikan Budaya pada Satuan Pendidikan Rintisan

Jurnal Pendidikan dan Kebudayaan, 2013
This study aims to obtain a picture related to the implementation of the cultural curriculum development efforts 300 units on preschool education, primary education, secondary education, exceptional education, and educational equality that has been ...
Sutjipto --
doaj   +1 more source

Cultural Studies and education: a dialogue of ‘disciplines’?

, 2022
In this opening contribution to the Special Issue Cultural Studies and Education: A Dialogue of Disciplines?, Bill Green and Andrew Hickey survey the pedagogical and disciplinary intersections of Cultural Studies and Education.
Bill Green, Green, Bill, Hickey, Andrew, Andrew Hickey   +3 more
core   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Bridging worlds: a study of academic skills, cultural exchange, and integration in UK higher education

Journal of Learning Development in Higher Education
This case study explores the experience of an Academic Skills Adviser and an international postgraduate student at a university in the North West of England in relation to academic skills, cultural exchange, and integration into higher education in the ...
Anthony D. Cliffe, Lin Chou
doaj   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Authenticity and brain health: a values-based perspective and cultural education approach. [PDF]

Front Neurol, 2023
Stirland LE, Ayele BA, Correa-Lopera C, Sturm VE.   +3 more
europepmc   +1 more source

Reconceptualising outdoor adventure education: Activity in search of an appropriate theory.

, 2009
Experiential approaches to learning underpin teaching and learning strategies in outdoor adventure education (OAE). Recent critiques of experiential learning have problematised the individualistic and overly cognitive focus of this approach which creates
Brown, Mike
core