Results 141 to 150 of about 6,748,108 (328)
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
THE IMPACT OF SOCIAL AND CULTURAL ENVIRONMENT ON THE ENTREPRENEURIAL ACTIVITY [PDF]
Considering that entrepreneurship is closely related to the environmental evolution and dynamism in which it take place, and depending of all its factors: economical, social, cultural, etc., this study tries to outline an overview of what the social and ...
Sorina- Andreea PUSCASU
core
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
Open Research EuropeComputer-assisted approaches to historical language comparison have made great progress during the past two decades. Scholars can now routinely use computational tools to annotate cognate sets, align words, and search for regularly recurring sound ...
Cristian Juárez +3 more
doaj +1 more source
On Selfish Memes: culture as complex adaptive system [PDF]
We present the formal definition of meme in the sense of the equivalence between memetics and the theory of cultural evolution. From the formal definition we find that culture can be seen analytically and persuade that memetic gives important role in the
Hokky Situngkir
core
Fidelity and the grain problem in cultural evolution
Synthese, 2021 M. Charbonneau, Pierrick Bourrat
semanticscholar +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
The emergence of polarised groups through source filtering
Humanities & Social Sciences CommunicationsPolarisation is a widespread societal issue, dividing populations into opposing groups whose beliefs may span multiple, seemingly unrelated, topics. This phenomenon creates distinct cultural groups with internally consistent yet mutually opposing beliefs,
Fredrik Jansson, Anandi Hattiangadi
doaj +1 more source
Evolution for our time: a theory of legal memetics [PDF]
The purpose of this paper is to explore the significance for legal thought of recent developments in evolutionary theory which are associated with the notion of 'memetics'.
Simon Deakin
core
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source