Results 171 to 180 of about 6,392,593 (355)

Emerging role of ARHGAP29 in melanoma cell phenotype switching

open access: yesMolecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster   +3 more
wiley   +1 more source

Hedonic Pricing Evaluation on Agritourism Activity in Italy: Local Culture-based or Facility-based? [PDF]

open access: yes
This paper focused on how and what diversified activities influence the price level of agritourism. A hypothesis that contrasts two directions was examined: facility-based and local culture-based activities.
Ciani, Adriano, Ohe, Yasuo
core   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

open access: yesMolecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici   +8 more
wiley   +1 more source

A revised digital edition of Wurm & Hattori’s Language Atlas of the Pacific Area

open access: yesScientific Data
Wurm & Hattori’s Language Atlas of the Pacific Area describes the geographic speaker areas of the languages and language varieties spoken in the Pacific. Thanks to the efforts of the Electronic Cultural Atlas Initiative, this monumental piece of work has
Robert Forkel, Harald Hammarström
doaj   +1 more source

The cultural evolution of teaching. [PDF]

open access: yesEvol Hum Sci, 2023
Brandl E, Mace R, Heyes C.
europepmc   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

open access: yesMolecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert   +13 more
wiley   +1 more source

The Evolution of Cost Control Systems: a Cultural Phenomenon [PDF]

open access: yes
This paper only aims at stimulating research and debate, starting from two ideas:• historically, cost control systems have undergone major changes by integrating an increasing level of instability;• the same pattern of evolution can be found in other ...
Alain Burlaud, Claude Simon
core  

In vitro properties of patient serum predict clinical outcome after high dose rate brachytherapy of hepatocellular carcinoma

open access: yesMolecular Oncology, EarlyView.
Following high dose rate brachytherapy (HDR‐BT) for hepatocellular carcinoma (HCC), patients were classified as responders and nonresponders. Post‐therapy serum induced increased BrdU incorporation and Cyclin E expression of Huh7 and HepG2 cells in nonresponders, but decreased levels in responders.
Lukas Salvermoser   +14 more
wiley   +1 more source

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