Results 191 to 200 of about 1,330,064 (298)

Context, Consequence, Coincidence, and Cumulative Cultural Evolution: Linking Creativity and Culturo-Behavioral Phenomena Together Using Systems Principles and Processes of Selection by Consequences. [PDF]

Perspect Behav Sci
Krispin JV.
europepmc   +1 more source

Generative cultural learning in children and adults: the role of compositionality and generativity in cultural evolution. [PDF]

Proc Biol Sci, 2023
Varallyay A, Beller N, Subiaul F.
europepmc   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Historicizing the liberal antiracism of Cultural Evolution. [PDF]

Hist Philos Life Sci
Brinitzer C.
europepmc   +1 more source

The Cultural Evolution of Medical Technologies : A Model of Sequential Treatments in the Medical Setting. [PDF]

Hum Nat, 2023
Hong Z.
europepmc   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

The neural underpinnings of repeated skill transfer in human cultural evolution. [PDF]

Front Psychol
Øhrn H, Sjursen EP, Specht K, Hugdahl K, Straffon LM, Bender A.   +5 more
europepmc   +1 more source

The importance of thinking about the future in culture and cumulative cultural evolution. [PDF]

Philos Trans R Soc Lond B Biol Sci, 2022
Vale GL, Coughlin C, Brosnan SF.
europepmc   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Half a century of quantitative cultural evolution. [PDF]

Proc Natl Acad Sci U S A
Fogarty L, Kandler A, Creanza N, Feldman MW.   +3 more
europepmc   +1 more source