Results 171 to 180 of about 1,330,064 (298)

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

The roles of cultural transmission and causal reasoning in the cultural evolution of technology. [PDF]

PNAS Nexus
Saral AS, Ibáñez de Aldecoa P, Derex M.   +2 more
europepmc   +1 more source

Agent-based models of the cultural evolution of occupational gender roles. [PDF]

R Soc Open Sci, 2023
Cross CP, Boothroyd LG, Jefferson CA.
europepmc   +1 more source

Natural selection for communication favours the cultural evolution of linguistic structure. [PDF]

, 2008
Kirby, Simon, Smith, Kenneth
core   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Cultural evolution in the laboratory: evolution of cooperative altruistic punishing. [PDF]

Evol Hum Sci
Baum WM, Richerson PJ.
europepmc   +1 more source

Cartography: Innateness or Convergent Cultural Evolution? [PDF]

Front Psychol, 2022
Satık D.
europepmc   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

African harps as units of cultural evolution: a cladistic analysis on their morphology. [PDF]

Evol Hum Sci
Strauch S, Lecointre G, Darlu P, Le Bomin S.   +3 more
europepmc   +1 more source

Multilevel cultural evolution: From new theory to practical applications. [PDF]

Proc Natl Acad Sci U S A, 2023
Wilson DS, Madhavan G, Gelfand MJ, Hayes SC, Atkins PWB, Colwell RR.   +5 more
europepmc   +1 more source