Results 201 to 210 of about 5,617,123 (302)

Historicizing the liberal antiracism of Cultural Evolution. [PDF]

Hist Philos Life Sci
Brinitzer C.
europepmc   +1 more source

The Cultural Evolution of Medical Technologies : A Model of Sequential Treatments in the Medical Setting. [PDF]

Hum Nat, 2023
Hong Z.
europepmc   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Half a century of quantitative cultural evolution. [PDF]

Proc Natl Acad Sci U S A
Fogarty L, Kandler A, Creanza N, Feldman MW.   +3 more
europepmc   +1 more source

The importance of thinking about the future in culture and cumulative cultural evolution. [PDF]

Philos Trans R Soc Lond B Biol Sci, 2022
Vale GL, Coughlin C, Brosnan SF.
europepmc   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

The neural underpinnings of repeated skill transfer in human cultural evolution. [PDF]

Front Psychol
Øhrn H, Sjursen EP, Specht K, Hugdahl K, Straffon LM, Bender A.   +5 more
europepmc   +1 more source

Human socio-cultural evolution in light of evolutionary transitions: introduction to the theme issue. [PDF]

Philos Trans R Soc Lond B Biol Sci, 2023
Carmel Y, Shavit A, Lamm E, Szathmáry E.   +3 more
europepmc   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

The cultural evolution of distortion in music (and other norms of mixed appeal). [PDF]

Philos Trans R Soc Lond B Biol Sci
Bryant GA, Smaldino PE.
europepmc   +1 more source