Results 251 to 260 of about 6,392,593 (355)

UNRAVELING BANGLADESH'S CULTURAL EVOLUTION IN THE LIGHT OF ITS ISLAMIC MIDDLE AGES: BRIDGING HISTORIES

Ehsanul Mahbub
openalex   +2 more sources

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Cultural evolution: A review of theoretical challenges. [PDF]

Evol Hum Sci
Nichols R, Charbonneau M, Chellappoo A, Davis T, Haidle M, Kimbrough EO, Moll H, Moore R, Scott-Phillips T, Purzycki BG, Segovia-Martin J.   +10 more
europepmc   +1 more source

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

Molecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking   +43 more
wiley   +1 more source

Outside Chinatown: the evolution of Manchester's Chinese Arts centre as a cultural translator for contemporary Chinese art [PDF]

, 2015
Rmc Kennedy
openalex  

The Bells - from Liturgical Artefact to Sculptural Installation and Social Memorial. An Interdisciplinary Survey on the Evolution of a Traditional Artefact to the Status of Social Symbol and Cultural Icon [PDF]

, 2019
Mihai Rusen, Pompiliu Alexandru
openalex   +1 more source

The characteristic time scale of cultural evolution. [PDF]

PNAS Nexus
Wand T, Hoyer D.
europepmc   +1 more source

Spatio-temporal evolution of supply-demand-support system coupling coordination and its influencing factors of Chinese cultural tourism [PDF]

Hang Zhang, Xingpeng Chen, Lili Pu
openalex   +1 more source

Human evolution: Cultural roots [PDF]

, 2012
Jeff Tollefson
openalex   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source