Results 141 to 150 of about 951,967 (336)

Exon 7 splicing of ERα predicts poor prognosis and increases phenotypic heterogeneity in luminal a subtype breast cancer

open access: yesFEBS Open Bio, EarlyView.
ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui   +10 more
wiley   +1 more source

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

open access: yesFEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake   +4 more
wiley   +1 more source

HUMAN NATURE OR HUMANITY: BETWEEN GENES AND VALUES [PDF]

open access: yes, 2012
We are within nature and culture, conditioned simultaneously by genes and meanings. This form of our self-understanding is the result of fundamental modifications that happened in modern philosophical anthropology and of the impact of the natural Science.
Tuchańska, Barbara
core  

Matrix metalloproteinase‐9 regulates cell adhesion and membrane protrusive activity of ovarian cancer cells

open access: yesFEBS Open Bio, EarlyView.
Matrix metalloproteinase‐9 (MMP9) drives ovarian cancer progression. Using MMP9‐null cells (M9‐KO) created from ovarian cancer cells, we found MMP9 loss did not block Epidermal Growth Factor (EGF)‐driven E‐cadherin dissolution or EMT but delayed and reduced EGF‐driven membrane protrusions. Transient MMP9 re‐expression drove membrane protrusion.
Claire Strauel   +8 more
wiley   +1 more source

EDUCAÇÃO EM CIÊNCIAS E A TEORIA DA ATIVIDADE CULTURAL-HISTÓRICA: CONTRIBUIÇÕES PARA A REFLEXÃO SOBRE TENSÕES NA PRÁTICA EDUCATIVA

open access: yesEnsaio Pesquisa em Educação em Ciências, 2014
Activity Theory has its origins in the works by Vygotsky and currently spans diverse fields of knowledge. Recently, much of Science Education research have used Socio-Cultural-Historical references, however their potential use is far from being achieved.
Juliano Camillo, Cristiano Mattos
doaj  

In Search of a Singular I: A Structurational Analysis of Passing [PDF]

open access: yes, 2005
It is easy to envision the socio-cultural phenomenon of passing as a relic of a bygone era, yet passing is markedly more. From a historical perspective, passing-as-white is a strategy of representation through which light-skinned, white-looking ...
Alesan, Dawkins Marcia
core   +1 more source

Iron homeostasis disruption and lipid peroxidation in skeletal muscle during short‐term immobilization

open access: yesFEBS Open Bio, EarlyView.
14‐day casting‐induced immobilization reduced gastrocnemius muscle mass and increased non‐heme iron and ferritin heavy chain levels. Despite iron accumulation, transferrin receptor 1 and iron regulatory protein 2 were paradoxically upregulated. Lipid peroxidation was elevated without compensatory antioxidant responses.
Haruka Yokogawa   +2 more
wiley   +1 more source

Canadian Contributions to Social Reproduction Feminism, Race and Embodied Labor [PDF]

open access: yes, 2008
Recent methodological advances in Canadian Social Reproduction Feminism foreground labor as a foundational concept of social theory and, as a result, address the structuralist bias critics of the paradigm have identified, while still grounding theory in ...
Ferguson, Sue
core   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

open access: yesFEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani   +6 more
wiley   +1 more source

Valuing Historic Places: Traditional and Contemporary Approaches [PDF]

open access: yes, 2010
Decisions about which older buildings, structures, and places should be conserved are fundamental to the practice of architectural conservation. Conservation professionals use the interrelated concepts of integrity, authenticity, and historical value to ...
Wells, Jeremy C.
core   +1 more source

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