Results 71 to 80 of about 20,808 (259)

Modernity, the Individual, and the Foundations of Cultural–Historical Activity Theory [PDF]

Mind, Culture, and Activity, 2007
It is argued that the problem of individual agency in relation to social institutions can be resolved within Cultural–Historical Activity Theory (CHAT) by the use of the “subject” as a unit of analysis. Such an approach implies a reaffirmation of the fundamental tenets of CHAT but also a critique of the concepts of society and culture, which are ...
openaire   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Working with historicity: tracing shifts in contraceptive use in the activity system of sex over time

Psychology in Society, 2012
Sexual activity, sexuality and responses to HIV and AIDS in a rural context in South Africa were studied using a cultural-historical activity theory framework. Activity theory directs the focus onto activity and emphasises the importance of an historical
Mary van der Riet
doaj  

Structure and Distortions of the Activity Autoregulation: a Growing Edge of the Cultural-Historical Activity Theory

Культурно-историческая психология
The problem setting of the paper stems from the idea of shifts in research contexts and explanatory emphases in the Cultural-Historical Activity Theory (CHAT) through the history of its development, specifically, from putting the concepts of ...
D.A. Leontiev
doaj   +1 more source

Unknown Vygotsky: Cultural-Historical Theory in the Context of Pavlov’s Theory of Higher Nervous Activity and H. Werner’s Differential Development Theory

Культурно-историческая психология, 2016
The position about the internal connection between the cultural-historical theory of development of higher mental functions of L.S. Vygotsky and two prominent theories of the 20th century is substatianted.
Chuprikova N.I.,
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Professional Learning from Disturbances in Healthcare: Managerialism and Compassion [PDF]

International Journal of Management, Knowledge and Learning, 2020
This study asks what behaviours might convert professional disturbances in maternity wards into opportunities for learning within healthcare and how that process is influenced by models of management and leadership.
Katie Willocks, Jem Bendell, Richard Little   +2 more
doaj  

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

CONTRIBUIÇÕES PARA COMPREENDER A FORMAÇÃO NA LICENCIATURA E NA DOCÊNCIA

Educação em Revista
RESUMO: A partir de projetos de formação de professores, integrando universidade e escolas públicas, analisam-se aspectos da atividade do licenciando e do professor, tendo por base os princípios da teoria histórico-cultural e da teoria da atividade.
Marisa da Silva Dias, Neusa Maria Marques de Souza   +1 more
doaj   +1 more source