Results 71 to 80 of about 951,967 (336)

Using Cultural Historical Activity Theory to understand how emerging technologies can mediate teaching and learning in a mathematics classroom: a review of literature

Research and Practice in Technology Enhanced Learning, 2019
The purpose of this paper was to review literature on the Cultural Historical Activity Theory (CHAT) and how it has been used to understand the mediation between emerging technologies and teaching and learning in a mathematics classroom. Specifically, it
M. S. Batiibwe
semanticscholar   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Design smart city apps using activity theory. [PDF]

, 2017
In this paper we describe an innovative approach to the design process of Smart City interventions. We tested it with participants enrolled in the Master\u2019s Degree program in \u201cInnovators in enterprise and public administration\u201d: the ...
Ferranti, C., Petrucco, C.
core   +1 more source

Understanding the role of objects in cross-disciplinary collaboration [PDF]

, 2012
In this paper we make a case for the use of multiple theoretical perspectives – theory on boundary objects, epistemic objects, cultural historical activity theory and objects as infrastructure - to understand the role of objects in cross-disciplinary ...
Bartel C. A., Corlett W. S., Davide Nicolini, Engeström Y., Gubrium J. F., Jacky Swan, Jeanne Mengis, Kaptelinin V., Knorr Cetina K., Latour B., Law J., Lawler E. E., Leont'ev A. N., Levina N., Miettinen R., Orr J. E., Pawlowski S. D., Rafaeli A., Rheinberger H.-J., Silverman B. S., Spradley J. P., Strauss A. L., Suchman L. A., Wartofsky M. W., Yanow D.   +24 more
core   +1 more source

Learning with computers: Generating insights into the development of cognitive tools using cultural historical activity theory

Australasian Journal of Educational Technology, 2019
Using computers as cognitive tools or mindtools has created impact in education since their introduction in the 1990s. One main characteristic is the notion of learning with computers as intellectual partners: engaging learners in higher level thinking ...
S. Tan
semanticscholar   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Marxism and Cultural Studies in the Development of Axel Honneth’s Theory of Recognition [PDF]

, 2012
This essay analyses the interaction between Marxism and Cultural Studies in the genesis of Honneth’s theory of recognition. I reconstruct the passages through which Honneth, by drawing on the writings of some of the ...
Piromalli, Eleonora
core   +1 more source

Cultural Historical Activity Theory: The Role of Tools and Tensions in Medical Education.

Academic medicine : journal of the Association of American Medical Colleges, 2019
Copyright © by the Association of American Medical Colleges. Unauthorized reproduction of this article is prohibited. Cultural historical activity theory (CHAT) provides a framework to analyze complex systems both in research and in curriculum design and
Douglas P. Larsen, L. Nimmon, L. Varpio
semanticscholar   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Teacher and Technology: The Computer In Education [PDF]

, 2006
This article is results of the research carried out between the years 2000 and 2001 in a Chilean high school, with the objective of studying the role of the computer in teaching.
Kaechele, Mónica
core