CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir +12 more
wiley +1 more source
Shifting Goals in Aesthetic Rhinoplasty: Eurocentric Ideals, Ethnic Background, and Cultural Identity. [PDF]
Atiyeh B +4 more
europepmc +1 more source
An empirical study on cultural identity measurement and its influence mechanism among heritage tourists. [PDF]
Fu Y, Luo JM.
europepmc +1 more source
Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source
Application of deep learning for transformation of Chinese traditional cultural narrative patterns and enhancement of cultural identity empowered by AIGC. [PDF]
Liu Y, Wang H.
europepmc +1 more source
The Impact of Cultural Memory and Cultural Identity in the Brand Value of Agricultural Heritage: A Moderated Mediation Model. [PDF]
Zheng Q, Zhang S, Liang J, Chen Y, Ye W.
europepmc +1 more source
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
Retracted: Influence of Degree of Chinese Cultural Identity and Performance Expectation on Consumption Attitude for Health Care of Traditional Chinese Medicine. [PDF]
Methods In Medicine CAM.
europepmc +1 more source

