Results 181 to 190 of about 2,011,690 (292)

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

The impact of English usage on social media on college students' interpersonal communication intentions: a dual mediating model of language confidence and English cultural identity. [PDF]

Front Psychol
Zhang Y, Wu Y, Chen Y, Zhang H.
europepmc   +1 more source

Europe’s Culture(s): Negotiating Cultural Meanings, Values, and Identities in the European Context [PDF]

, 2018
Matthias Göbel, Verónica Benet‐Martínez, Batja Mesquita, Ayşe K. Üskül   +3 more
openalex   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Investigating the role of Arabic language in sustaining socio-cultural identity and family values in Emirati society. [PDF]

Front Sociol
Zakarneh B, Mahmoud DAM.
europepmc   +1 more source

Cultural identity central to Native American persistence in science. [PDF]

Cult Stud Sci Educ, 2022
Chow-Garcia N, Lee N, Svihla V, Sohn C, Willie S, Holsti M, Wandinger-Ness A.   +6 more
europepmc   +1 more source

Women’s Roles and Participation in Rituals in the Maintenance of Cultural Identity: A Study of the Malaysian Iyers

, 2015
Lokasundari Vijaya Sankar
openalex   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Cross-cultural teaching and foreign teacher identity in Singapore

, 2019
Sun Yee Yip, Eisuke Saito, Zane M. Diamond   +2 more
openalex   +1 more source

Language and Cultural Identity in Postcolonial African Literature: The Case of Translating Buchi Emecheta into Spanish [PDF]

, 2018
Isabel Pascua Febles
openalex   +1 more source