Results 151 to 160 of about 228,071 (312)
Images of Culture – Then and Now
Etnoantropološki Problemi, 2016 Marking the 60th Anniversary of the Ethnographic Institute of the SASA, Kruševac 2007.
openaire +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
To date, research has been equivocal when comparing the body image perceptions of elite athletes, habitual exercisers, and inactive young females. Understanding body image perceptions of athletes, exercisers and inactive females is significant due to ...
Reeve, Victoria
core
The living lab - Swinburne Design Factory
, 2014 This photograph originally appeared in the 2014 Research student photography and image competition held to celebrate National Science Week (Aug 16-24).
Coddington, Alicen, Alicen Coddington
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Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Consumer´s appreciation of regional image and the perceived quality of rural tourism [PDF]
Tourists' perception of regional image is critical as regards the degree of satisfaction obtained from the overall tourism experience. The present paper analyses the ways in which a region's image is incorporated into the tourist products and the overall
Petrou, Anastasia +2 more
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Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Image and Video Processing for Cultural Heritage
EURASIP Journal on Image and Video Processing, 2009 Nikolaidis Nikos +3 more
doaj +2 more sources