MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
ShilpoBangla: A dataset of Bangladeshi cultural product images with alternative texts in Bangla and English. [PDF]
Data BriefAhmed SMN +4 more
europepmc +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Cluster Oriented Image Retrieval System with Context Based Color Feature Subspace Selection
, 2010 This paper presents a cluster oriented image retrieval system with context recognition mechanism for selection subspaces of color features. Our idea to implement a context in the image retrieval system is how to recognize the most important features in ...
Barakbah, Ali Ridho
core
Resisting epistemic loss in AI image generation. [PDF]
Patterns (N Y)Safir AH, Blackwell AF, Debnath R.
europepmc +1 more source
, 2011 O audiovisual transborda os limites formais das mídias quando chega à Internet e aos dispositivos móveis: célere e mutante escapa à normalização e controle habituados. São imagens e narrativas em grande parte ainda espelhadas naquelas às quais estávamos habituados, mas que, só por inflacionarem o mercado pela abundância e por não se sujeitarem ao ...
openaire +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Transformation of artistic style and innovative design of oriental folk patterns based on AIGC Technology-A case study of Zhuxian town new year paintings from China. [PDF]
PLoS OneZhang J +5 more
europepmc +1 more source
Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis
Molecular Oncology, EarlyView.This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht +3 more
wiley +1 more source
Quantifying emotional resonance of cultural symbols across visual media: a multimodal learning approach for heritage tourism. [PDF]
Sci RepWu M, Zhang C, Lyu L, Jiang X.
europepmc +1 more source