Results 111 to 120 of about 779,176 (289)
The Distribution Function: at the Heart of managing Cultural-Product Industries [PDF]
Cultural industries (music, publishing, movies, television) faced similar trends in recent years : growing importance of distribution, raising costs in promotion, concentrating demand on fewer products, restructuring value added chain.
Pierre-Jean Benghozi, Thomas Paris
core
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Children’s Hospital Environment Design Based on AHP/QFD and Other Theoretical Models
BuildingsSpatial environmental factors can effectively alleviate children’s fear of the medical environment when they seek medical treatment. This study focuses on the special environmental space of a children’s hospital, thoroughly considering the emotional ...
Haohua Zheng +4 more
doaj +1 more source
Communication of creativeness in business media
Creativity Studies, 2018 Creativity has been traditionally associated and even identified with artistry. However, it is being perceived as an impetus for the development of leadership and technologies innovation, and is characteristic of activities that for long have not been ...
Živilė Sederevičiūtė-Pačiauskienė +4 more
doaj +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Cultural entrepreneurship: A review of the literature
Tourism & Management Studies, 2020 The paper provides a comprehensive review of Scopus-indexed English language publications on entrepreneurship in cultural and creative industries and the arts.
Nevena Dobreva , Stanislav Ivanov
doaj
The Futurism of Hip Hop: Space, Electro and Science Fiction in Rap
Open Cultural Studies, 2018 In the early 1980s, an important facet of hip hop culture developed a style of music known as electro-rap, much of which carries narratives linked to science fiction, fantasy and references to arcade games and comic books.
de Paor-Evans Adam
doaj +1 more source
Molecular Oncology, EarlyView.Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source