Results 101 to 110 of about 4,648,312 (258)

Self-discontinuity in behavioral addictions: A psychodynamic framework

Addictive Behaviors Reports
Models based on substance use criteria have been employed to classify maladaptive engagement in various everyday activities as genuine addictions. However, symptom-based models have potential limitations, which includes in some cases reduced clinical ...
Gianluca Santoro, Alessandro Musetti, Antonino Costanzo, Adriano Schimmenti   +3 more
doaj   +1 more source

CIIC Submission - Satellite Accounts Discussion Paper - August 2013.pdf

, 2015
Creative Industries Innovation Centre submission regarding ABS Discussion paper, Cultural & Creative Activity Satellite Accounts. Specifically responds to 'Component 1 - Cultural and Creative Industry Supply Chains' and 'Component 2 - Cultural and ...
Creative Industries Innovation Centre
core  

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

Molecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Sarah Reed, Edita Ritmejeryte, Rohan Lourie, Naven Chetty, Kaltin Ferguson, Carlos Salomon   +9 more
wiley   +1 more source

Why do creative industries cluster? An analysis of the determinants of clustering of creative industries [PDF]

Creative industries tend to concentrate mainly around large- and medium-sized cities, forming creative local production systems. The text analyses the forces behind clustering of creative industries to provide the first empirical explanation of the ...
Rafael Boix, Luciana Lazzeretti, Francesco Capone   +2 more
core  

A role for eIF5A in translational control of stress‐inducible proteins in multiple myeloma cell lines

Molecular Oncology, EarlyView.
Loss of eIF5A rewires thapsigargin‐mediated endoplasmic reticulum stress responses in multiple myeloma cells by selective translation of mRNA transcripts, consequently dampening thapsigargin‐induced unfolded protein response (UPR) activation and shifting the balance from induction of apoptosis toward cell survival and proliferation.
Demi Both, Ingrid A. M. Derks, Raphaël Vanleyssem, Marine Leclercq, Najla El Hachem, Pierre Close, Eric Eldering, Marco Vincent Haselager   +7 more
wiley   +1 more source

NAPRT loss promotes lung tumor initiation and growth through AKT signaling independently of NAD+ biosynthesis

Molecular Oncology, EarlyView.
Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh, Ji Yun Jang, Yoon Jeon, Gi‐Cheon Kim, Hwanho Lee, Jooyoung Lee, Ju‐Hwa Kim, Hakhyun Kim, Minjee Kim, Ho‐Keun Kwon, Ho Lee, Hyun Seok Kim   +11 more
wiley   +1 more source

Enhancing political trust through media diversity in post-pandemic China: policy insights for achieving sustainable development goals

Frontiers in Communication
IntroductionPolitical trust is essential for achieving the United Nations’ Sustainable Development Goals (SDGs), especially in the context of new media’s impact during health crises.
Ming Wei, Lingbo Fu, Chengyu Xiong, Hongpeng Fu   +3 more
doaj   +1 more source

Do creative industries cluster? Mapping Creative Local Production Systems in Italy [PDF]

An important debate on the role of creativity and culture as factors of local economic development is distinctly emerging. Despite the emphasis put on the theoretical definition of these concepts, it is necessary to strengthen comparative research for ...
Rafael Boix, Luciana Lazzeretti, Francesco Capone   +2 more
core  

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Data-Driven Innovation in the Creative Industries

The creative industries – the place where art, business, and technology meet in economic activity – have been hugely affected by the relatively recent digitalisation (and often monetisation) of work, home, relationships, and leisure.
Osborne, Nicola, Jones, Vikki, Speed, Chris, Terras, Melissa   +3 more
core   +2 more sources