Results 111 to 120 of about 783,916 (309)
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
FEBS Open Bio, EarlyView.CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point +7 more
wiley +1 more source
Children’s Hospital Environment Design Based on AHP/QFD and Other Theoretical Models
BuildingsSpatial environmental factors can effectively alleviate children’s fear of the medical environment when they seek medical treatment. This study focuses on the special environmental space of a children’s hospital, thoroughly considering the emotional ...
Haohua Zheng +4 more
doaj +1 more source
The Futurism of Hip Hop: Space, Electro and Science Fiction in Rap
Open Cultural Studies, 2018 In the early 1980s, an important facet of hip hop culture developed a style of music known as electro-rap, much of which carries narratives linked to science fiction, fantasy and references to arcade games and comic books.
de Paor-Evans Adam
doaj +1 more source
The city mouse and the country mouse: the geography of creativity and cultural production in Italy [PDF]
Through census employment data we analyze the evolving structure of the Italian cultural economy and highlights diverging spatial and organizational patterns of cultural production systems in urban and regional areas.
Bertacchini Enrico, Borrione Paola
core
FEBS Open Bio, EarlyView.Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold +11 more
wiley +1 more source
Cultural entrepreneurship: A review of the literature
Tourism & Management Studies, 2020 The paper provides a comprehensive review of Scopus-indexed English language publications on entrepreneurship in cultural and creative industries and the arts.
Nevena Dobreva , Stanislav Ivanov
doaj
Book review: developing cultural industries: learning from the palimpsest of practice by Christiaan De Beukelaer [PDF]
, 2015 What role have culture and the creative industries come to play as ‘tools’ for social and economic development? In Developing Cultural Industries: Learning from the Palimpsest of Practice, Christiaan De Beukelaer examines the implementation of culturally
Vickery, Jonathan
core
BMI‐1 modulation and trafficking during M phase in diffuse intrinsic pontine glioma
FEBS Open Bio, EarlyView.The schematic illustrates BMI‐1 phosphorylation during M phase, which triggers its translocation from the nucleus to the cytoplasm. In cycling cells, BMI‐1 functions within the PRC1 complex to mediate H2A K119 monoubiquitination. Following PTC596‐induced M phase arrest, phosphorylated BMI‐1 dissociates from PRC1 and is exported to the cytoplasm via its
Banlanjo Umaru +6 more
wiley +1 more source