Results 51 to 60 of about 783,916 (309)

Emmanuel Levinas and Ethical Materialism

Religions, 2021
The article discusses concrete and material aspects of Levinas’s ethical metaphysics. Firstly, the paper shows that, in contrast to several alternative modern conceptions of subjectivity, the Levinasian subject is not at a safe distance from the world ...
Jolanta Saldukaitytė
doaj   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Images vs Words: a Study for a Visual Rhetoric

img journal, 2023
The universality of figurative arts underlines the expressive potential of images, while ideograms document the origin of writing in drawing, demonstrating its ability to configure itself as a language through the development of recognizable codes.
Michela Rossi, Greta Milino
doaj   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Soft power, global governance of cultural industries and rising powers: the case of China [PDF]

, 2016
This article addresses the importance of cultural industries for the strengthening of the soft power of the rising powers and it seeks to understand how the cultural industries allow rising powers to shape the structures of their international ...
Vlassis, Antonios
core   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Moebius strip enterprises and expertise in the creative industries: new challenges for lifelong learning? [PDF]

, 2007
The paper argues that the emergence of a new mode of production – co-configuration is generating new modes of expertise that EU policies for lifelong learning are not designed to support professionals to develop. It maintains that this change can be seen
Beynon H., Billett S., Boden M., Bourdieu P., Bourdieu P., Brandom R., Coffe D., Csikszentmihalyi M., David Guile, Engeström Y., Engeström Y., Engeström Y., Florida R., Frith S., Gardner H., Ghosal S., Ghoshal S., Griffiths T., Guile D., Guile D., Howkins J., Kaufman J., Knorr Cetina K., Lave J., Nonaka I., Piore M., Sabel C., Sternberg R., Unwin L., Victor B., Warmington P., Wood S.   +31 more
core   +3 more sources

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Integrating Western and non-Western cultural expressions to further cultural and creative tourism: a case study [PDF]

, 2013
The term cultural industries was coined more than half a century ago, but at the beginning of the twenty-first century, the broader concept of creative industries, covering a wide range of cultural, design and digital activity, captured the imagination ...
Ainsley M., Aldiss B. W., Balshaw M., Catalani A., Department for Communities and Local Government (DCLG), Department of Culture, Media and Sport (DCMS), English J. F., Fabiani J. L., Florida R., Giorgi L., Habermas J., Kirshenblatt-Gimblett B., Landry C., Landry C., Manchester City Council (MCC), Manchester City Council (MCC), Manchester City Council (MCC), Manchester City Council Cultural Engagement Task and Finish Group, McNulty R., Nightingale E., Picard D., Raymond C., Richards G., Richards G., Sarup M., Scott A., Shaw S., Smith L., Smith M., Stebbins R. A., United Nations Educational, Scientific and Cultural Organisation (UNESCO), Wurzburger R.   +31 more
core   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source