Results 111 to 120 of about 1,539,709 (312)
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
Carbon emission inequality of urban and rural households in China from 2000 to 2020
Scientific ReportsThe entrenched urban–rural dualism in China has historically impeded socioeconomic advancement. Analyzing disparities in carbon emissions (CEs) of urban and rural households (URH) proves instrumental not only for achieving equitable public service ...
Ting Zhou, Xiao Zhou, Qiang Wang
doaj +1 more source
A Poet as an Art Manager: A Maria Osipova Project “Masha Writes” (2018)
Филологический класс, 2020 The article discusses the content and cultural meaning of the art project of the top manager of the UMMC Maria Osipova. The methodological basis for analysis is the concept of a book of poems as a complex artistic unity that implements a single plan and ...
doaj +1 more source
Culture, Cultural Industries and Creative Industries.
, 2006 La culture, passée et sédimentée en un patrimoine, créée dans les processus de créativité, apparaît comme facteur de production dans les industries culturelles mais aussi dans des industries, parfois très éloignées, comme le parfum, la mode, la restauration. Culture et industrie se trouvent alors en interrelation.
openaire +1 more source
CULTURAL TOURISM AND SUSTAINABLE DEVELOPMENT [PDF]
The cultural tourism covers a wide range of interdependent activities, connected with other economic branches, which play a major role in the developing tourism industry. The people's increasing amount of leisure time, the tourists' changing interest and
Ioan Franc, Valeriu +1 more
core
“Style City” How London became a Fashion Capital [PDF]
, 2009 The book explains and explores in a critical as well as a celebratory way the birth of today’s London Designer identity and the evolution of London Fashion Week.
Dagworthy, Wendy +2 more
core
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Images du Travail, Travail des ImagesBoth academic literature on video game production and professionals in this sector share a diversity rhetoric with the idea that a diverse team necessarily create more diverse and inclusive characters.
Lise Cottet
doaj +1 more source