Results 31 to 40 of about 171,199 (308)

The artistic complexity of the Antikythera Mechanism: a comprehensive tutorial

open access: yesProceedings (European Academy of Sciences and Arts), 2023
Recovered in 1901, from a first-century BC shipwreck, the Antikythera Mechanism is considered to be the oldest extant complex geared device. It was constructed in ~150 BCE and was essentially an analog computer, an astronomical and calendrical device ...
Kyriakos Efstathiou   +2 more
doaj   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

open access: yesFEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa   +3 more
wiley   +1 more source

A Critical Review on the Analysis of Metal Soaps in Oil Paintings

open access: yesChemistryOpen, 2021
Up to 70 % of the oil paintings conserved in collections present metal soaps, which result from the chemical reaction between metal ions present in the painted layers and free fatty acids from the lipidic binders.
Prof. Francesca Caterina Izzo   +3 more
doaj   +1 more source

Cultural Heritage Informatics

open access: yesProceedings of the Annual Conference of CAIS / Actes du congrès annuel de l'ACSI
This paper briefly traces the informational history and contemporary formalization of Cultural Heritage Informatics as a distinct domain within IS/LIS, motivated by recent calls for more critical, ethical, and community-oriented interrogations of IS/LIS resulting from recent debates on our professional identity.
Tyler Youngman   +2 more
openaire   +1 more source

Approaching Evaluation in Youth Community Informatics [PDF]

open access: yes, 2009
In the Youth Community Informatics project, young people from disadvantaged communities use audio and video recording and editing tools, GPS/GIS, presentation software, graphics, and other digital technologies as the means for addressing community needs.
Bruce, Bertram C.   +2 more
core  

The promotion of data sharing in pharmacoepidemiology [PDF]

open access: yes, 2014
This article addresses the role of pharmacoepidemiology in patient safety and the crucial role of data sharing in ensuring that such activities occur. Against the backdrop of proposed reforms of European data protection legislation, it considers whether ...
Sethi, Nayha
core   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

open access: yesMolecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley   +5 more
wiley   +1 more source

Gamification vs. Privacy: Identifying and Analysing the Major Concerns

open access: yesFuture Internet, 2019
Gamification, the use of game design elements in applications that are not games, has been developed to provide attractive environments and maintain user interest in several domains.
Aikaterini-Georgia Mavroeidi   +3 more
doaj   +1 more source

Virtual patients reflecting the clinical reality of primary care – a useful tool to improve cultural competence

open access: yesBMC Medical Education, 2021
Background Virtual patients are educational tools that may be described as case-based interactive computer simulations of clinical scenarios. In terms of learning outcomes, improved clinical reasoning skills and knowledge acquisition have been shown. For
Erica Rothlind   +4 more
doaj   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

open access: yesMolecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel   +6 more
wiley   +1 more source

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