Results 41 to 50 of about 171,199 (308)

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Critical Analysis of the Materials Used by the Venetian Artist Guido Cadorin (1892–1976) during the Mid-20th Century, Using a Multi-Analytical Approach

Heritage, 2023
The present study sought to expand on and confirm the already available information on the painting materials used by the Venetian artist Guido Cadorin (1892–1976).
Erik Guillermo Morales Toledo, Teodora Raicu, Laura Falchi, Elisabetta Barisoni, Matteo Piccolo, Francesca Caterina Izzo   +5 more
doaj   +1 more source

Information society policies 2.0: a critical analysis of the potential and pitfalls of social computing & informatics in the light of e-inclusion [PDF]

, 2010
In this paper we reflect on how research and policies can and/or should help in the development of a sustainable information society for all. More specifically, we critically investigate how social computing & informatics can entail both potential and ...
Verdegem, Pieter
core   +1 more source

Heidegger, technology and sustainability: between intentionality, accountability and empowerment [PDF]

, 2017
Transition is the adequate term for characterising contemporary societies. Norms and values are in transit, led by a technological revolution, which is, in itself, the tip of the iceberg of millenary social and cultural changes.
Duarte, Rogério, Jacquinet, Marc, Nobre, Ângela Lacerda   +2 more
core   +1 more source

Sudden anaerobization in Amphibacillus xylanus increases intracellular labile ferrous iron and inhibits cell growth

FEBS Open Bio, EarlyView.
Abruptly changing from aerobic to anaerobic conditions (sudden anaerobization) induced growth inhibition and a significant increase in intracellular labile ferrous iron in the aerotolerant anaerobe Amphibacillus xylanus. We found that free flavins mediate efficient electron transfer from NADH to ferric iron under anaerobic conditions, suggesting that ...
Shinya Kimata, Yoichi Sakai, Keisuke Tanaka, Etsuro Yoshimura, Ken Kitano, Morio Ishikawa, Tadahiro Nakamoto, Tsutomu Takayama, Hirofumi Inoue, Kaho Nomura, Tomonori Suzuki, Masataka Uchino, Akira Abe, Youichi Niimura   +13 more
wiley   +1 more source

Discovery and Targeted Proteomic Studies Reveal Striatal Markers Validated for Huntington's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Clinical trials for Huntington's disease (HD) enrolling persons before clinical motor diagnosis (CMD) lack validated biomarkers. This study aimed to conduct an unbiased discovery analysis and a targeted examination of proteomic biomarkers scrutinized by clinical validation. Methods Cerebrospinal fluid was obtained from PREDICT‐HD and
Daniel Chelsky, Cara Joyce, H. Jeremy Bockholt, Paul A. Rudnick, William H. Adams, Fiona McAllister, Justin W. Smock, Michael A. Newton, Jane S. Paulsen   +8 more
wiley   +1 more source

Populist Political Communication on Instagram in the 2024 European Elections

Media and Communication
With the rapid rise of social media usage and its integration into daily life, platforms like X (formerly known as Twitter) and Instagram have emerged as essential tools for political communication. Political actors use these platforms to attract voters,
Sophia Messini
doaj   +1 more source

Toward Addressing Location Privacy Issues: New Affiliations with Social and Location Attributes

Future Internet, 2019
Nowadays, location-sharing applications (LSA) within social media enable users to share their location information at different levels of precision. Users on their side are willing to disclose this kind of information in order to represent themselves in ...
Katerina Vgena, Angeliki Kitsiou, Christos Kalloniatis, Dimitris Kavroudakis, Stefanos Gritzalis   +4 more
doaj   +1 more source

Challenges of ultra large scale integration of biomedical computing systems [PDF]

, 2005
The NCRI Informatics Initiative is overseeing the implementation of an informatics framework for the UK cancer research community. The framework advocates an integrated multidisciplinary method of working between scientific and medical communities. Key
Begent, R., Brady, J.M., Finkelstein, A., Gavaghan, D., Kerr, P., Parkinson, H., Reddington, F., Wilkinson, J.M.   +7 more
core   +1 more source

Sertraline Treatment Can Mimic Niemann‐Pick Type C Biomarker Profile: A Diagnostic Pitfall

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Oxysterols (cholestane‐3β,5α,6β‐triol and 7‐ketocholesterol) and N‐palmitoyl‐O‐phosphocholineserine (PPCS) are sensitive biomarkers for Niemann‐Pick disease type C (NPC) screening. However, false‐positive results occur, with a biomarker profile suggestive of NPC despite the absence of pathogenic variants in genes involved in NPC or ...
Maria Makrygianni, Cecile Pagan, Antony Citterio‐Quentin, Isabelle Rouvet, Giulia Dingeo, Cyril Hanin, Claudine Laurent‐Levinson, Samia Pichard, Bénédicte Héron, Clément Gourguechon, Daniele Mandia, Jerome Guitton, Carole Lacout, Nicolas Schleinitz, Florient Potier, Olivier Flabeau, Elsa Besse‐Pinot, Foudil Lamari, Magali Pettazzoni, Yann Nadjar   +19 more
wiley   +1 more source