Results 101 to 110 of about 1,974,528 (310)
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Tumultuous materials. Decorated coarse ware in Late Iron Age Emilia [PDF]
Studia HercyniaIn the Emilian Po plain, during the Late Iron Age (4th and 3rd century BCE), an unprecedented and heteroge neous class of handmade coarse and decorated ceramics emerged in certain sites.
Lorenzo Zamboni
doaj
The Lived Experience of Cultural Immersion [PDF]
, 2013 This article presents the findings of a grounded theory study of 3 graduate students\u27 lived experience of cultural immersion. Results indicated that participants experienced 3 phases (goal setting, interaction, and evaluation) and 4 themes (bias ...
Avrus, Elaine M. +3 more
core +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
The Merging of Traditional Chinese Medicine and Western Medicine in China: Old Ideas Cross-Culturally Communicated Through New Perspectives [PDF]
, 1989 The People\u27s Republic of China is engaged in reforms which involve development of its economic, cultural, educational, and political processes. The need for reform has been realized as China has fallen behind the development of the western world in ...
Schnell, James A.
core +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Assertiveness and tolerance in cross-cultural interaction
Социальная психология и общество, 2017 The article is devoted to the theoretical analysis of the concepts of tolerance and assertiveness. Problem of contemporary cross-cultural interaction is the need to shift strategy of tolerance on strategy of assertiveness.
Pochebut L.G., Beznosov D.S.
doaj +1 more source
Translation as cross-cultural interaction [PDF]
, 2017 The article approaches translation as intercultural interaction between the author, the translator and the reader in the shared cultural space, with the focus on changes that the source text concept undergoes.
Андрієнко, Т. П.
core