Results 121 to 130 of about 1,974,528 (310)
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source
Economic Cooperation and Social Identity: Towards a Model of Economic Cross-Cultural Integration [PDF]
In arguing that borders not only should be understood as economic barriers to trade, but also as cultural barriers to interaction, this paper attempts to operationalize a broader interpretation of borders with regards to economic cross-cultural ...
Olsen, Karsten Bjerring
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Cybersocialism. Group Consciousness in Transnational Communities [PDF]
, 1998 An important new type of community is emerging with the rapid advances in communication technologies: communities that cross cultural and political boundaries to engage in a commerce of information exchange.
Sudweeks, Fay
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Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source
İslam Öncesi Dönemden Emevi Döneminin Sonuna Kadar Tercüme Faaliyetleri
Eskiyeni, 2013 Tercüme faaliyetleri geçmişten bugüne milletlerin etkileşimi sonucu olarak bilginin paylaşılmasını sağlamış, paylaşılan bu bilgiler nesilden nesile aktarılıp günümüze ulaşarak büyük bir birikim oluşturmuştur.
Fatma Betül Aslan
doaj
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
Farmers' social identity and crop genetic diversity. The G x E x S model [PDF]
, 2012 A better knowledge of factors organizing crop genetic diversity in situ increases the efficiency of diversity analyses and conservation strategies, and requires collaboration between social and biological disciplines.
Coppens D'Eeckenbrugge, Géo +1 more
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Molecular Oncology, EarlyView.Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano +6 more
wiley +1 more source
Management Letters/Cuadernos de Gestión, 2008 This paper poses, from a theoretical perspective, the role that may have Internet as a key factor to foster the cultural convergence among countries. In this regard, we refl ect about a central theoretic proposal, taking as main reference the dynamic ...
IGNACIO TAMAYO TORRES +2 more
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