Results 31 to 40 of about 44,773 (264)

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

Assessing Consumer Preferences and Willingness to Pay for Agricultural Landscape Attributes in Lithuania

Land, 2022
Agricultural activities play an important role in shaping landscape, in particular, in Lithuania, where agricultural land accounts for more than half of the surface land.
Lucia Rocchi, Anastasija Novikova, Bernardas Vaznonis   +2 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Research on the Cultural Landscape Features and Regional Variations of Traditional Villages and Dwellings in Multicultural Blending Areas: A Case Study of the Jiangxi-Anhui Junction Region

Applied Sciences
Traditional villages face many difficulties in the era of globalization, especially in light of fast industrialization and urbanization. The breakdown of settlement patterns and the erosion of local characteristics and cultural identities pose critical ...
Yapeng Duan, Mingxia Chen, Yue Liu, Yuan Wang, Li Zhang   +4 more
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Plant roots affect free-living diazotroph communities in temperate grassland soils despite decades of fertilization

Communications Biology
Fixation of atmospheric N2 by free-living diazotrophs accounts for an important proportion of nitrogen naturally introduced to temperate grasslands. The effect of plants or fertilization on the general microbial community has been extensively studied ...
Marlies Dietrich, Christopher Panhölzl, Roey Angel, Andrew T. Giguere, Dania Randi, Bela Hausmann, Craig W. Herbold, Erich M. Pötsch, Andreas Schaumberger, Stephanie A. Eichorst, Dagmar Woebken   +10 more
doaj   +1 more source

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Landscape-Infrastructure: shifts of meaning for changing cities

Ri-vista: Ricerche per la Progettazione del Paesaggio, 2019
Given the current global situation and the problems we need to face, landscape architects are more than ever before confronted with the task of planning and transforming complex cultural landscapes.
Marta Buoro
doaj   +1 more source