Results 51 to 60 of about 44,773 (264)

CULTURAL NEEDS AND THEIR IMPACT ON THE TRANSFORMATION OF CONTEMPORARY URBAN LIVING IN MACEDONIA [PDF]

Journal of Process Management and New Technologies, 2014
Cultural needs are subject to monitoring of urban planners, leading to satisfying end-user. In Macedonia, Skopje or objects with their cultural use are part of the urban growth area of the city, located in the highest concentration in the downtown ...
Petar Namicev, Ekaterina Namiceva
doaj  

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Multiple Values and System Mechanisms of Rice Terrace Systems from the Perspective of Heritage Comparison

Fengjing Yuanlin
ObjectiveTerraced fields are common around the world, and those with high quality, such as Honghe Hani Rice Terraces in China, Rice Terraces of the Philippine Cordillera in the Philippines, and Subak Irrigation System in Indonesia, have all been listed ...
Yuliang YANG, Xuerun YU, Yuanmei JIAO, Songlin SUN   +3 more
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Types of cultural palimpsest landscapes in the Mediterranean basin delimitation and mapping

European Journal of Geography, 2017
Cultural heritage sites in the Mediterranean basin reflect long–term cultural and land-use changes associated with different regional civilizations. We integrated data on historical heritage sites and civilization areas using GIS-mapping and modeling ...
Oxana A. Klimanova, Eugeny Yu. Kolbowsky   +1 more
doaj   +2 more sources

Construction and characterization of cultural landscape genomic maps of traditional miao communities in Leigong Mountain

Journal of Asian Architecture and Building Engineering
In the era of farming civilization, traditional villages serve as carriers for value retention. In the context of urban – rural integration, exploring the means for protecting the traditional Miao villages in Leigong Mountain, Qiandongnan, holds great ...
Han Gu, Hongyu Chen, Yiting Luo, Ke Xu
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Globalization of Higher Education in Malaysia

Georgia Journal of College Student Affairs, 2016
The purpose of this paper is to highlight how globalization and the development of knowledgebased economy is effecting the higher education system of Malaysia.
Isaac Taylor
doaj   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source