Results 61 to 70 of about 44,773 (264)

The Interplay between Cultural Heritage and Urban Morphology: A Case Study of uMlazi Cultural Landscape [PDF]

E-Journal of Humanities, Arts and Social Sciences
Historic urban areas are a crucial component of urban heritage, arguably embodying the collective memory of urban development and often possessing distinctive urban textures and cultural attributes. This study analyses the relationship between intangible
Leonard Chitongo , Maheshvari Naidu
doaj   +1 more source

Cancer cell‐intrinsic type 1 interferon: production, signaling, and outcomes within sex‐biased, female malignancies

Molecular Oncology, EarlyView.
The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant, Nora Badiner, Sharon Asariah, Kiera McGivney, Vishwa Shah, Tise Suzuki, Yevgeniya J. Ioffe, Juli J. Unternaehrer   +7 more
wiley   +1 more source

Model of interaction of geographic, cultural and sacral landscapes

Неофилология, 2015
The interaction of geographical, cultural and sacred landscapes is considered. The concept “landscape” is analyzed and its interdisciplinary character is emphasized. It is proposed to divide the definition of phenomenon on the concept “theoretical models”
Nataliya Nikolaevna LAVRINOVA
doaj  

“Wind” and “Earth” Dialogue: A Study on the Connotation and Protection Strategy of “Water-Distributing Shrine” Landscape Structure—Taking Taiyuan City as an Example

Land
In the dialogue between “wind” and “earth”, terroir-built heritage and the natural environment together construct the cultural landscape of agrarian civilization.
Ruijie Zhang, Xinyuan Jiang, Haoran Li, Zhe Zhang   +3 more
doaj   +1 more source

Landscape function analysis as a base of rural development strategies

Journal of Environmental Geography, 2017
Research on ecosystem services and landscape functions are highly important in landscape ecology, landscape planning and open space design. The terms of ecosystem service and landscape function have been evolved parallel to each other in the scientific ...
Filepné Kovács Krisztina, Fóris Edina Dancsokné, Valánszki István   +2 more
doaj   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Landscape change and perception along historical railway: the case of Yunnan-Vietnam Railway, China

Journal of Environmental Engineering and Landscape Management
Against the background of environmental change, this study investigates the relationship between landscape changes and perceptions along the historical railway using a combination of Historical Geographic Information Systems (HGIS) and Fuzzy-set ...
Kun Sang, Luoning Xiang, Guiye Lin
doaj   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Formation Process and Spatial Representation of Tourist Destination Personality from the Perspective of Cultural Heritage: Application in Traditional Villages in Ancient Huizhou, China

Land
Tourism destinations are cultural heritage and spatial landscape systems of organic coexistence between humans and the Earth, and are formed through the long historical evolution of a specific geographical environment. With the development of large-scale
Kai Ren, Jin Xu
doaj   +1 more source