Results 71 to 80 of about 13,852,248 (340)

VIRTUAL MUSEUMS FOR LANDSCAPE VALORIZATION AND COMMUNICATION [PDF]

The International Archives of the Photogrammetry, Remote Sensing and Spatial Information Sciences, 2017
Research in the domain of landscape virtual reconstructions has been mainly focused on digitization and recording inside GIS systems, or real time visualization, paying a minor attention to the development of a methodological approach for the landscape
E. Pietroni
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IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Cultural Dimensions And CRM Systems: A Cross-Cultural Case Study’ [PDF]

, 2006
Cultural dimensions are often identified as a crucial influence on the success or failure of Information Systems in general and Customer Relationship Management Systems (CRM) in particular.
Brooks, L, Ali, M, Alshawi, S
core   +5 more sources

Il ruolo dei pattern agricoli nella creazione di paesaggi rurali identitari

Ri-vista: Ricerche per la Progettazione del Paesaggio, 2015
In various historical, geographic and cultural contexts, inhabitants have drawn forms and structures on the landscape fruit of their social, economic and production systems.
Daniele Torreggiani, Enrica Dall’Ara, Patrizia Tassinari   +2 more
doaj   +1 more source

Man-made landscape in Adyghe culture system

Вестник Костромского государственного университета им. Н.А. Некрасова, 2010
The article is devoted to the topical problem of search and introduction in project practice of new ecological concepts through acquaintance with traditional features of ethnic man-made landscapes. The authors of article, opening essence and ethnic originality of the Adyghe garden-wood it is given reason prove Adyghe garden-wood simultaneously is the ...
Makhotlova, M., Shautsukova, L.
openaire   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Geographical Information System for the Cultural Heritage and Protected Landscape of Regione Toscana [PDF]

International Journal of Heritage in the Digital Era, 2012
LaMMA Consortium, with collaboration of Regione Toscana and Ministero per i Beni e le Attività Culturali (MiBAC), has created the web Geographical Information System for Cultural Heritage and Protected Landscape of Regione Toscana. This system now makes it possible to access the digital maps and the digital archives of archaeological, architectural ...
R. Costantini, L. Angeli, R. Ferrari, L. Innocenti, M. Del Buono   +4 more
openaire   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

CULTURAL NEEDS AND THEIR IMPACT ON THE TRANSFORMATION OF CONTEMPORARY URBAN LIVING IN MACEDONIA [PDF]

Journal of Process Management and New Technologies, 2014
Cultural needs are subject to monitoring of urban planners, leading to satisfying end-user. In Macedonia, Skopje or objects with their cultural use are part of the urban growth area of the city, located in the highest concentration in the downtown ...
Petar Namicev, Ekaterina Namiceva
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