Results 31 to 40 of about 92,421 (253)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Aspects of memory acts: transnational cultural memory and ethics

Journal of Aesthetics & Culture, 2011
In the paper I use arguments from Ludwig Wittgenstein, John L. Austin and Judith Butler to show how the concepts of collective memory and of performativity can help to formulate some ideas about what an ethics of memory can deal with.
Steffi Hobuß
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Construction of "Red Memory" Knowledge Graph Based on Multi-source Heterogeneous Data Mining

Zhishi guanli luntan, 2020
[Purpose/significance] Red cultural resources are produced in the process of the Chinese nation and the Chinese Communists' pursuit of truth. Constructing "red memory" by organizing and mining knowledge of red cultural resources can not only enhance ...
Guo Jiaxin
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Cultural memory and military tradition [PDF]

Srpska Politička Misao
In this article, author aims to offer an in-depth analysis of the place and meaning of cultural memory in the contemporary era of human civilization, observing it from the perspective of the military.
Stanar Dragan
doaj   +1 more source

EXPLICATING FEMALE BODY AS A GEOGRAPHY OF MEMORY: THE COMPARATIVE SILENT REBELLION OF THE PSYCHE IN CHOPIN AND HAWTHORNE / KADIN BEDENİNİN HAFIZA ÜZERINDEN TEFSİR EDİLİŞİ: SESSİZ DİRENİŞİN CHOPIN VE HAWTHORNE ÜZERİNDEN KARŞILAŞTIRMALI OLARAK İNCELENMESİ [PDF]

Folklor/Edebiyat, 2017
What is both ideological and magical about ‘memory’ is the fact that it is both singular and plural which acts as a bridge between the personal and the collective. The example of that kind of a bridge is especially represented through literature.
Esin Kumlu
doaj   +1 more source

In Search of the Fragments of Recollection

Sanglap: Journal of Literary and Cultural Inquiry, 2023
Culture, memory, and identity are intricately connected terms. Memory is not just an individual experience but plays a prominent role in the establishment of both individual and cultural identity. Jan Assmann, in his essay “Collective Memory and Cultural
Divyasree J S, B. Sajeetha
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

From museum to memory institution: the politics of European culture online

Museum & Society, 2017
Museums, libraries and archives have long been considered the retainers of some form of collective memory. Within the last twenty years, the term ‘memory institution’ has been coined to describe these entities, which is symptomatic of the fact that such ...
Elizabeth Stainforth
doaj   +1 more source