Results 51 to 60 of about 1,108,521 (299)
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
"New Songs of the Battlefield": Songs and Memories of the Chinese Cultural Revolution [PDF]
, 2004 This dissertation focuses on a five-volume anthology of songs published from 1972 to 1976 known as "Zhandi Xinge," literally "New Songs of the Battlefield." The songs represent a significant portion of the limited musical expression during a period in ...
Bryant, Lei Ouyang
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Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
A Note on Ricœur’s Early Notion of Cultural Memory
Études Ricoeuriennes / Ricoeur Studies, 2019 This essay considers Paul Ricœur’s early notion of cultural memory from 1956-1960. He discusses it in two texts: “What does Humanism Mean?” and the slightly later The Symbolism of Evil.
Suzi Adams
doaj +1 more source
Cultural Memory Archetypes [PDF]
, 2015 Actuality of the theme is determined by the interest to the phenomenon of archetype and its ability to translate the content of cultural memory. The definition of “memory” contest is expanded and the history of the phenomenon's study is examined in the ...
Korneeva, A. Yu. +3 more
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Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
, 2020 Within the course of a day people perform innumerable feats of memory. They are involved in remembering when they search for their keys, find their way through a city, reminisce on episodes from their past, or join in commemorations such as independence days and religious rituals.
+5 more sources
‘You don’t need influence … all you need is your first opportunity!’: The Early Broadcast Talent Show and the BBC [PDF]
, 2014 Popular histories of the reality talent show often position programmes like Opportunity Knocks as key generic precursors to the popular formats of today.
Holmes, Su
core +1 more source
Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis
FEBS Open Bio, EarlyView.Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho +4 more
wiley +1 more source
Cultural differences in complex addition: efficient Chinese versus adaptive Belgians and Canadians [PDF]
, 2009 In the present study, the authors tested the effects of working-memory load on math problem solving in 3 different cultures: Flemish-speaking Belgians, English-speaking Canadians, and Chinese-speaking Chinese currently living in Canada.
Imbo, Ineke, LeFevre, Jo-Anne
core +1 more source