Results 121 to 130 of about 2,622,105 (306)
Culture Rules: The Foundations of the Rule of Law and Other Norms of Governance [PDF]
, 2003 This study presents evidence about relations between national culture and social institutions. We operationalize culture with data on cultural dimensions for over 50 nations adopted from cross-cultural psychology and generate testable hypotheses about ...
Goldschmidt, Chanan +2 more
core
TRIM40 Drives Pathological Cardiac Hypertrophy and Heart Failure via Ubiquitination of PKN2
Advanced Science, EarlyView.This study identifies the E3 ligase TRIM40 as a key driver of pathological cardiac hypertrophy. TRIM40 binds PKN2 via its B‐box domain and, through its C29‐dependent catalytic activity, mediates K63‐linked ubiquitination of PKN2. This modification enhances PKN2 phosphorylation at Ser815, thereby driving hypertrophy.
Risheng Zhao +12 more
wiley +1 more source
Leveraging Artificial Intelligence and Large Language Models for Cancer Immunotherapy
Advanced Science, EarlyView.Cancer immunotherapy faces challenges in predicting treatment responses and understanding resistance mechanisms. Artificial intelligence (AI) and machine learning (ML) offer powerful solutions for cancer immunotherapy in patient stratification, biomarker discovery, treatment strategy optimization, and foundation model development.
Xinchao Wu +4 more
wiley +1 more source
Adjusting for cultural effects on countries’ education policy efficiency:an application of conditional full frontiers measures [PDF]
In this paper using Data Envelopment Analysis (DEA) we evaluate the influence of national culture on education policy efficiency for 20 OECD countries.
Halkos, George, Tzeremes, Nickolaos
core +1 more source
Integrating Human Intestinal Organoids into FDA'S New Approach Methodologies for Drug Discovery
Advanced Science, EarlyView.Illustration summarizes how human intestinal organoids (HIOs) are becoming transformative in preclinical research. Preclinical drug discovery pipelines often rely on animal models for ADMET studies, even though interspecies ADME gaps, poor external validity, and high attrition rates are common.
Debarun Patra +6 more
wiley +1 more source
Culture and Urban Revitalization: A Harvest Document [PDF]
, 2007 Advocates have long argued that the economic benefits of the arts and culture provide a firm rationale for public support. Recent scholarship on the "creative class" and "creative economy" is simply the latest effort to link cultural expression to ...
Mark J. Stern, Susan C. Seifert
core
Redefining the Health Risk of Battery Materials Through a Biologically Transformed Metal Mixture
Advanced Science, EarlyView.Inhaled NCM particles undergo lysosomal degradation, releasing complex ion mixtures that induce systemic impact. The impact is determined by a critical balance between antagonistic Ni‐Co interactions and synergistic Mn effects. To capture these complexities in risk assessment, we develop an IAI model, ensuring a more accurate quantitative risk ...
Ze Zhang +11 more
wiley +1 more source
Advanced Science, EarlyView.This review examines the evolution of bioprinting toward minimally invasive in situ strategies for internal organ regeneration. It defines the technological roadmap from handheld systems to advanced minimally invasive bioprinting platforms, positioning soft robotics as a core enabler.
Duc Tu Vu +9 more
wiley +1 more source
Community Versus Assimilation: A Study In American Assimilation at Saint Joseph\u27s Indian Industrial School [PDF]
, 1997 No govemment policy has had more of an impact on American Indians than the boarding school movement of the early to mid-twentieth century. This movement isolated American Indian children from their homes and communities and attempted to assimilate them ...
Shillinger, Sarah
core +1 more source
Deciphering the Impact of RAC1‐SPTAN1 in ARPKD Cystogenesis Using Multifaceted Models
Advanced Science, EarlyView.Distal/connecting tubules expressing SLC8A1 have been suggested as a potential origin of ARPKD cysts. SPTAN1 has been identified as a key molecule in ARPKD cyst formation. Restoring SPTAN1 in PKHD1−/− organoids reduced cyst formation, normalized calcium levels, and decreased RAC1/c‐FOS expression, highlighting SPTAN1's role in ARPKD and the potential ...
Shohei Kuraoka +9 more
wiley +1 more source