Results 51 to 60 of about 2,643,399 (303)

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon   +13 more
wiley   +1 more source

Crisis en las políticas públicas de cultura. La planeación cultural del gobierno de López Obrador

open access: yesAlteridades, 2020
Based on documentary analysis, this article holds that there is a public cultural policy crisis. The first sign of this crisis can be found in how objectives and goals are defined as part of the critique of the neoliberal period, in spite of similarities
EDUARDO NIVÓN BOLÁN
doaj   +1 more source

Mapping State Cultural Policy: The State of Washington [PDF]

open access: yes, 2003
State-level funding for the arts, humanities, heritage, and allied forms of culture is an important source of financial support, dwarfing the aid provided by the National Endowment for the Arts.
Colleen Grogan   +5 more
core  

Icelandic Cultural Policy [PDF]

open access: yes, 2013
In Mars 2013 the Icelandic Parliament decided upon the first formal “Icelandic Cultural Policy”. In this article that document is examined in light of debates concerning the concept of deliberate cultural policy making.
Sigurjonsson, Njordur
core   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

open access: yesFEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane   +11 more
wiley   +1 more source

Anti-Space: the political complexion of an inner city art gallery

open access: yesJournal of Architecture and Urbanism, 2014
The subject of this paper is an inner city artist-run gallery called Eastside Projects. As part of an historical trend in artistrun spaces, Eastside Projects have innovated a strategic approach to post-industrial space, their location and role within the
Jonathan P. Vickery
doaj   +1 more source

[Review of] Paul A. Scanlon, ed. Stories from Central and Southern Africa [PDF]

open access: yes, 1987
Any work in the prestigious paperback African Writers Series commands immediate attention and respect. As policy makers and policy breakers wrestle about the South African question -- newly discovering the horrors of an inequality that has existed for ...
Jordan, W. A., III
core   +1 more source

Intergenerational Cultural Programs for Older People in Long-term Care Institutions: Latvian Case [PDF]

open access: yes, 2017
An ageing population is a global phenomenon that takes place in Latvia, too. The active ageing policy is a social response to social challenges caused by demographic changes.
Rasnača, Līga   +1 more
core   +3 more sources

Why human connection is the true metric of research success

open access: yesFEBS Open Bio, EarlyView.
Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan   +3 more
wiley   +1 more source

Feasibility and Tolerability of Performing Portable MRI for Neurological Disorders in an Outpatient Neurology Clinic: A Prospective Cohort

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Accessing brain magnetic resonance imaging (MRI) can be challenging, especially for underserved patients, which may lead to disparities in neurological diagnosis. Method This mixed‐methods study enrolled adults with one of four neurological disorders: mild cognitive impairment or dementia of the Alzheimer type, multiple sclerosis ...
Maya L. Mastick   +19 more
wiley   +1 more source

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