Results 101 to 110 of about 449,443 (354)

An Activity‐Dependent NEPAS–PTX3 Axis Links Neurovascular and Myelin Deficits to Cognitive Impairment

Advanced Science, EarlyView.
An activity‐dependent pathway links prefrontal circuit hypoactivity to cognitive impairment. Reduced PVA–mPFC activity upregulates NEPAS, which suppresses PTX3 secretion, leading to impaired angiogenesis, myelin deficits, and memory decline. Rescue is achieved by NEPAS knockdown or chemogenetic circuit activation.
Boya Hu, Zifei Chen, Bingmei Sun, Jiale Gao, Jiale Xu, Xiaochun Guo, Fenfei Gao, Zhongsi Wang, Jie Wu, Xiaoyu Ji, Peipei Liu, Bing Huang   +11 more
wiley   +1 more source

The Importance of Religion and Spirituality in Cultural Psychiatry: Reply to Drs Persad and Oyewumi. [PDF]

Can J Psychiatry, 2022
Kirmayer LJ, Andermann L, Fung K, Guzder J, Jarvis GE.   +4 more
europepmc   +1 more source

Endoplasmic Reticulum Geometry Dictates Neuronal Bursting via Calcium Store Refill Rates and Exposes Selective Neuronal Vulnerability

Advanced Science, EarlyView.
The ER's continuous tubular network is maintained by ER‐shaping proteins whose mutation or dysregulation contributes to neurodegenerative diseases. Here, we show that ER morphology sets the speed of Ca2+ store replenishment between firing events. Disrupting ER continuity slows intra‐ER Ca2+ redistribution from extracellular refill (SOCE) sites, driving
Valentina Davi, Pierre Parutto, Yuyi Zhang, Tasuku Konno, Cecile Crapart, Raquel Pereira, John P. Franklin, Mosab Ali Awadelkareem, Daniel C Maddison, Michael J. Devine, Edgar R. Gomes, Joseph Chambers, Elena Koslover, Edward Avezov   +13 more
wiley   +1 more source

Big boys don't cry: Depression and men [PDF]

, 2008
Men are a numerical minority group receiving a diagnosis of, and treatment for, depression. However, community surveys of men and of their mental health issues (e.g. suicide and alcoholism) have led some to suggest that many more men have depression than
Branney, P, White, A
core   +1 more source

Dysregulation of Oral Microbial Eicosapentaenoic Acid Induced by Chronic Restraint Stress Exacerbates Periodontitis via M1 Macrophage Polarization

Advanced Science, EarlyView.
ABSTRACT The intricate interplay between chronic psychological stress and periodontitis, mediated by oral microbiota and macrophage polarization, remains largely enigmatic. Here, we demonstrate that chronic restraint stress (CRS) exacerbates periodontitis by inducing oral microbial dysbiosis and a consequential shift in host metabolism.
Shihong Luo, Fangzhi Lou, Peiran Yang, Yu Zhang, Li Yan, Yunmei Dong, Bing Yang, Haiyang Wang, Yiyun Liu, Juncai Pu, Richard D. Cannon, Peng Xie, Ping Ji, Xin Jin   +13 more
wiley   +1 more source

Chinese Forensic Psychiatry: History, Development and Challenges

Journal of Forensic Science and Medicine, 2015
China has a long history of forensic psychiatry, which can be traced even back to Zhou dynasty (11 th century B.C.). However, modern forensic psychiatry has not been set up in China until the 1970s.
Li Xue, Yan-Wei Shi, James L Knoll, Hu Zhao   +3 more
doaj   +1 more source

Guidelines for Training in Cultural Psychiatry. [PDF]

Can J Psychiatry, 2021
Kirmayer LJ, Fung K, Rousseau C, Lo HT, Menzies P, Guzder J, Ganesan S, Andermann L, McKenzie K.   +8 more
europepmc   +1 more source

Lynn Gamwell and Nancy Tomes, Madness in America: cultural and medical perceptions of mental illness before 1914, Cornell Studies in the History of Psychiatry, Ithaca and London, Cornell University Press, 1995, pp. 182, illus., £31.50 (0-8014-3161-1). [PDF]

, 1996
Jonathan Andrews
openalex   +1 more source

Mental health care and resistance to fascism [PDF]

, 2009
Mental health nurses have a critical stake in resisting the right-wing ideology of British fascism. Particularly concerning is the contemporary effort of the British National Party (BNP) to gain credibility and electoral support by the strategic re ...
Allen, Audini, Barnes, Ben-Sefer, Benedict, Benedict, Bhui, Boast, Browne, Brěchon, Burleigh, Burstow, Busfield, Chesler, Clarke, Cochrane, Cogdell, Cohrane, Committee of Inquiry, Connell, Connell, Dalal, Dean, Department of Health, Department of Health, Dowbiggin, Easlea, Francis, Friedlander, Fromm, Geertz, Georges, Georges, Glover, Grekul, Harrison, Hassenfeld, Healthcare Commission, Care Services Improvement Partnership, National Institute for Mental Health in England, Healthcare Commission, Mental Health Act Commission, National Institute for Mental Health in England, Herrnstein, Husbands, Jones, Keating, Kramer, Lagerwey, Lawson, LeVay, Lieberman, Liebling, Lipstadt, Littlewood, Luther, Lynn, MacPherson, Marcuse, Mason, Masson, McGovern, McKeown, McKeown, McKie, Michalsen, Mikton, Miles, Minnis, Moodley, Morgan, Mostert, National Health Service Executive, National Institute for Mental Health England, Newman, NMC, Noble, Nolan, Odegaard, Ost, Parker, Parker, Parry-Crooke, Prins, Rattansi, Reich, Rogers, Rogers, Rushton, Rustin, Rwgellera, Seeman, Segal, Sprinks, Steppe, Stowell-Smith, Stowell-Smith, Taylor, Thomas, Unison, Unison, Ware, Williams, Wolfensberger, Worell, Younge   +101 more
core   +1 more source

18β‐Glycyrrhetinic Acid and a Nano‐Liposomal Formulation Alleviate Depression‐Like Behaviors via the Microglial mTOR‐Autophagy‐NLRP3 Axis

Advanced Science, EarlyView.
Using a novel zebrafish‐based inflammatory screening strategy, we screened and identified 18β‐glycyrrhetinic acid (18β‐GA) as a promising anti‐inflammatory candidate. We uncover a microglial mTOR–autophagy–NLRP3 axis that constitutes the mechanistic core of 18β‐GA–mediated neuroprotection.
Hua Gan, Haitao Yuan, Wenjun Zhu, Xiaokang Xie, Shen Zhou, Wenzhi Hao, Xiaowei Mo, Lian Yang, Xiaojuan Li, Junshan Liu, Lijuan Deng, Jiaxu Chen   +11 more
wiley   +1 more source